Abacavir-lamivudine-zidovudine Oral Tablet
Name: Abacavir-lamivudine-zidovudine Oral Tablet
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Highlights for abacavir-lamivudine-zidovudine
Abacavir/lamivudine/zidovudine is an oral medication used to treat HIV infection in combination with other drugs.
Each tablet contains three drugs: abacavir sulfate, lamivudine, and zidovudine.
This drug is available as a brand-name drug and in a generic form.IMPORTANT INFORMATION
FDA warning See Details
May cause muscle problems See Details
Increased heart attack risk See Details
What is abacavir/lamivudine/zidovudine?
Abacavir/lamivudine/zidovudine is a prescription drug that comes as an oral tablet. It’s available as a brand-name drug and in a generic form. Generic drugs usually cost less. In some cases, they may not be available in every strength or form as the brand-name version.
This medication comes as a single tablet that contains three drugs: abacavir, lamivudine, and zidovudine. It’s important to know about all the drugs in the combination because each drug may affect you in a different way.
Why it's used
This drug is used to treat HIV infection. It can’t cure HIV infection, but it may help control it. It’s approved to treat people who weigh at least 88 pounds (40 kg).
This drug is used as part of a combination therapy. That means you’ll need to take it in combination with other drugs.
How it works
This drug blocks an enzyme called reverse transcriptase. HIV needs this enzyme to make copies of itself in your body. Blocking reverse transcriptase may limit the virus’s ability to spread in your body. However, this drug has to be combined with other antiretroviral drugs to control HIV infection effectively.
Abacavir-lamivudine-zidovudine Side Effects
Most Common Side Effects
The most common side effects that occur with Trizivir include:
malaise and fatigue
nausea and vomiting
muscle pain (myopathy)
Serious Side Effects
If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.
severe, potentially fatal hypersensitivity reactions. Symptoms may include:
- nausea and vomiting
- trouble breathing
- sore throat
blood toxicity and bone marrow suppression, leading to anemia or neutropenia. Symptoms may include:
- picking up infections easily
increased risk of heart attack in people with a history of coronary heart disease
lactic acidosis and liver enlargement. Symptoms may include:
- swelling of your abdomen
Abacavir-lamivudine-zidovudine May Interact with Other Medications
Trizivir can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.
Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.
Trizivir may interact with alcohol. Tell your doctor about drinking alcohol while taking this medication.
Medications That Might Interact with This DrugDrugs that contain other forms of abacavir, lamivudine, or zidovudine
- abacavir (Ziagen)
- lamivudine/zidovudine (Combivir and generic)
- lamivudine (Epivir or Epivir-HBV)
- zidovudine (Retrovir)
- abacavir/lamivudine (Epzicom)
- ganciclovir (Cytovene). This is an intravenous antiretroviral drug. Using both ganciclovir and zidovudine can increase the risk of toxic effects from zidovudine.
- stavudine (Zerit)
- interferon alfa, alone or with ribavirin. There are many brands and generics of these drugs, which are used to treat hepatitis C virus infection, some forms of cancer, and other infections. Most of these drugs are injectable. All of these drugs are managed by specialist doctors and specialty pharmacies. If you’re treated for any of these conditions, ask your doctor if you should take Trizivir.
Note: If you’re being treated for cancer or are being treated with other drugs that prevent your bone marrow from making red and white blood cells, you should not take lamivudine/zidovudine. This is not common. If you’re not sure, talk to your doctor before taking this drug.Pain drug
People with kidney disease
Kidney disease may affect your ability to clear this drug from your body. If that happens, drug levels could get too high in your body and become toxic. This drug comes in just one strength, so it’s not possible to adjust your dose. If you have kidney disease, your doctor may decide to give you a different treatment.
People with liver disease
Abacavir/lamivudine/zidovudine is processed in your liver. If you have liver disease, the amount of each drug in abacavir/lamivudine/zidovudine may be too much for your liver to process. Your doctor may decide to give you a different treatment.
There haven’t been enough studies done in humans to be certain how this drug might affect a fetus. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
This drug should be used during pregnancy only if the potential benefits outweigh the risks. If you take this drug while pregnant, ask your doctor about taking part in the Antiretroviral Pregnancy Registry (APR), which tracks results of this drug usage.
Women who are breast-feeding
According to the Centers for Disease Control and Prevention, you shouldn’t breastfeed your infant if you have HIV. There is a risk of passing HIV to your baby.
Additionally, all three drugs in this medication are passed through human breast milk. If you breastfeed while taking these drugs, your baby could become resistant to them. This could make treatment difficult if your child becomes infected with HIV.
People older than 65 years often have reduced kidney function and may require a dose lower than the amount of the drugs included in a tablet. Depending on your kidney function, your doctor may recommend a different treatment.
When to call the doctor
Call your doctor if you experience:
- night sweats
- sore throat
- joint pain
These symptoms may be a sign the drug isn’t working, and you may need a different treatment.
This drug may cause a serious, potentially fatal hypersensitivity reaction. These reactions have happened to people taking abacavir, one of the drugs in abacavir/lamivudine/zidovudine. Signs of a hypersensitivity reaction may include:
- nausea and vomiting
- trouble breathing
- sore throat
Your risk for having this reaction is higher if you have the HLA-B*5701 gene. You may be tested for the gene before starting this drug. If you’ve had abacavir before and had a hypersensitivity reaction, you shouldn’t take it again.
How to Take abacavir-lamivudine-zidovudine (Dosage)
All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:
- your age
- the condition being treated
- how severe your condition is
- other medical conditions you have
- how you react to the first dose
What Are You Taking This Medication For?HIV infection
Generic: Abacavir-lamivudine-zidovudineForm: Oral Tablet Strength: 300 mg abacavir/150 mg lamivudine/300 mg zidovudine
Brand: TrizivirForm: Oral Tablet Strength: 300 mg abacavir/150 mg lamivudine/300 mg zidovudine Adult Dosage (ages 18-64 years and weighing at least 88 pounds [40 kg])
One tablet taken twice per day in evenly spaced doses.Child Dosage (ages 0-17 years and weighing at least 88 pounds [40 kg])
One tablet taken twice per day in evenly spaced doses.Senior Dosage (ages 65 years and older)
People older than 65 years often have reduced kidney function and may require a dose lower than the amount of the drugs included in a Trizivir tablet. Depending on your kidney function, your doctor may recommend a different treatment.Special considerations
Kidney Disease: Kidney disease may reduce how fast this drug is removed from your body. If that happens, drug levels in your body could get too high and become toxic. Trizivir comes in one strength only. It’s not possible to adjust your dose. If you have kidney disease, your doctor may decide to give you a different treatment.Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you. Important considerations for taking this drug