Acamprosate Calcium

Name: Acamprosate Calcium

Introduction

Synthetic homotaurine derivative that interacts with glutamate and GABA neurotransmitter systems in the CNS.1 7

Actions

  • Decreases glutamatergic transmission and modulates neuronal hyperexcitability during withdrawal from alcohol.7

  • Reduces voluntary intake of alcohol in alcohol-dependent animals.1 7 Acamprosate is not known to cause alcohol aversion.1 7

  • Alcohol ingestion does not result in disulfiram-like reactions.1

Advice to Patients

  • Risk of psychomotor impairment; importance of exercising caution while driving or operating hazardous machinery until the effects of the drug on the individual are known.1

  • Risk of suicidality; importance of patients, families, and caregivers notifying clinicians of emergence of suicidality or symptoms of depression.1

  • Importance of continuing therapy as directed by their clinician, even in the event of a relapse.1

  • Importance of discussing any renewed use of alcohol with their clinician.1

  • Advise patients that acamprosate helps maintain abstinence only when used as part of a treatment program that includes counseling and other supportive measures.1

  • Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.1

  • Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as any concomitant illnesses.1

  • Importance of informing patients of other important precautionary information.1 (See Cautions)

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

Acamprosate Calcium

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Oral

Tablets, delayed-release (enteric-coated)

333 mg

Campral (with propylene glycol)

Forest

Patient information

Physicians are advised to discuss the following issues with patients for whom they prescribe Campral.

Renal Impairment

A lower dose is recommended for patients with moderate renal impairment. Campral is contraindicated in patients with severe renal impairment (creatine clearance of ≤ 30 mL/min). [see DOSAGE AND ADMINISTRATION, CONTRAINDICATIONS, WARNINGS AND PRECAUTIONS and Use in Specific Populations]

Suicidality And Depression

Families and caregivers of patients being treated with Campral should be alerted to the need to monitor patients for the emergence of symptoms of depression or suicidality, and to report such symptoms to the patient's health care provider.[see WARNINGS AND PRECAUTIONS]

Alcohol Withdrawal

Use of Campral does not eliminate or diminish withdrawal symptoms. [see WARNINGS AND PRECAUTIONS]

Pregnancy And Breast Feeding

  • Advise patients to notify their physician if they become pregnant or intend to become pregnant during therapy.
  • Advise patients to notify their physician if they are breast-feeding.

Relapse To Drinking

  • Advise patients to continue Campral therapy as directed, even in the event of relapse and remind them to discuss any renewed drinking with their physicians.
  • Advise patients that Campral has been shown to help maintain abstinence only when used as a part of a treatment program that includes counseling and support.

What is the most important information i should know about acamprosate (campral)?

You should not use this medication if you are allergic to acamprosate, or if you have severe kidney disease.

Acamprosate will not treat or prevent alcohol withdrawal symptoms.

Before you take acamprosate, tell your doctor if you have any type of kidney problem. You may need a dose adjustment or special tests to safely use this medication.

You may have thoughts about suicide while you are taking acamprosate. Tell your doctor if you feel depressed or have any suicidal thoughts or actions during treatment.

Your family or other caregivers should also be alert to changes in your mood or behavior. Make sure your caregivers know how to contact your doctor in case you have mood changes or suicidal thoughts or actions.

Acamprosate can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Take this medication for the full prescribed length of time, even if you relapse and drink alcohol. While you are taking acamprosate, tell your doctor about any alcoholic drinks you consume, no matter how many.

What should i discuss with my healthcare provider before taking acamprosate (campral)?

You should not use this medication if you are allergic to acamprosate, or if you have severe kidney disease.

Acamprosate will not treat or prevent alcohol withdrawal symptoms.

Before you take acamprosate, tell your doctor if you have any type of kidney problem. You may need a dose adjustment or special tests to safely use this medication.

FDA pregnancy category C. It is not known whether acamprosate is harmful to an unborn baby. Before taking this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether acamprosate passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

You may have thoughts about suicide while you are taking acamprosate. Tell your doctor if you feel depressed or have any suicidal thoughts or actions during treatment.

Your family or other caregivers should also be alert to changes in your mood or behavior. Make sure your caregivers know how to contact your doctor in case you have mood changes or suicidal thoughts or actions.

Where can i get more information?

Your pharmacist can provide more information about acamprosate.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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