Acetaminophen and caffeine

Name: Acetaminophen and caffeine

What is the most important information I should know about acetaminophen and caffeine?

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death. Call your doctor at once if you have nausea, pain in your upper stomach, itching, loss of appetite, dark urine, clay-colored stools, or jaundice (yellowing of your skin or eyes).

Ask a doctor or pharmacist before using any other cold, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in many combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.

In rare cases, acetaminophen may cause a severe skin reaction. Stop taking this medicine and call your doctor right away if you have skin redness or a rash that spreads and causes blistering and peeling.

If OVERDOSE is suspected

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Acetaminophen and Caffeine?

  • Store at room temperature.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.

Pharmacologic Category

  • Analgesic, Nonopioid

Use Labeled Indications

Pain: For the temporary relief of pain caused by headache or muscle aches

Dosing Renal Impairment

There are no dosage adjustments provided in the manufacturer's labeling. Also see individual agents.

Test Interactions

See individual agents.

Usual Adult Dose for Cold Symptoms

12 years of age or older:
Initial dose: Caffeine 130 mg-acetaminophen 1000 mg orally every 6 hours as needed
Maximum dose: Caffeine 520 mg-acetaminophen 4000 mg orally in 24 hours

Use(s): For the temporary relief of the minor pain of headache, sinusitis, colds, muscular aches, menstrual discomfort, toothache, and arthritis pain.

Renal Dose Adjustments

Data not available