Acetaminophen, Dextromethorphan, Phenylephrine, and Diphenhydramine

Name: Acetaminophen, Dextromethorphan, Phenylephrine, and Diphenhydramine

Uses of Acetaminophen, Dextromethorphan, Phenylephrine, and Diphenhydramine

  • It is used to treat nose stuffiness.
  • It is used to ease allergy signs.
  • It is used to relieve coughing.
  • It is used to ease pain and fever.

What do I need to tell my doctor BEFORE I take Acetaminophen, Dextromethorphan, Phenylephrine, and Diphenhydramine?

  • If you have an allergy to acetaminophen, dextromethorphan, phenylephrine, and diphenhydramine or any part of this medicine.
  • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
  • If you have taken certain drugs used for low mood (depression) like isocarboxazid, phenelzine, or tranylcypromine or drugs used for Parkinson's disease like selegiline or rasagiline in the last 14 days. Taking acetaminophen, dextromethorphan, phenylephrine, and diphenhydramine within 14 days of those drugs can cause very bad high blood pressure.
  • If you have a cough with a lot of mucous.
  • If you have a long-term cough caused by smoking or being around smoke, or lung problems like asthma or emphysema.

This is not a list of all drugs or health problems that interact with this medicine.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take acetaminophen, dextromethorphan, phenylephrine, and diphenhydramine with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

What are some things I need to know or do while I take Acetaminophen, Dextromethorphan, Phenylephrine, and Diphenhydramine?

  • Tell all of your health care providers that you take this medicine. This includes your doctors, nurses, pharmacists, and dentists.
  • Do not take more than what your doctor told you to take. Taking more than you are told may raise your chance of very bad side effects.
  • Do not take acetaminophen, dextromethorphan, phenylephrine, and diphenhydramine for longer than you were told by your doctor.
  • Avoid driving and doing other tasks or actions that call for you to be alert until you see how this medicine affects you.
  • Avoid drinking alcohol while taking acetaminophen, dextromethorphan, phenylephrine, and diphenhydramine.
  • Talk with your doctor before you use other drugs and natural products that slow your actions.
  • Do not use with other products that have diphenhydramine.
  • Avoid other sources of acetaminophen. Check labels closely. Too much acetaminophen may cause problems.
  • Very bad and sometimes deadly liver problems have happened with the use of acetaminophen. Some people needed a liver transplant. Liver problems happened most often in people taking more than 4,000 mg (milligrams) in a day. People were often taking more than one drug with acetaminophen in it. Talk with your doctor.
  • Call your doctor right away if you take more than 4,000 mg (milligrams) of acetaminophen in a day, even if you feel well.
  • If you have phenylketonuria (PKU), talk with your doctor. Some products have phenylalanine.
  • This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take this medicine.
  • Use with care in children. Talk with the doctor.
  • Do not give acetaminophen, dextromethorphan, phenylephrine, and diphenhydramine to a child younger than 4 years of age.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this medicine while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.
  • Not able to pass urine or change in how much urine is passed.
  • A very bad skin reaction (Stevens-Johnson syndrome/toxic epidermal necrolysis) may happen. It can cause very bad health problems that may not go away, and sometimes death. Get medical help right away if you have signs like red, swollen, blistered, or peeling skin (with or without fever); red or irritated eyes; or sores in your mouth, throat, nose, or eyes.

What are some other side effects of Acetaminophen, Dextromethorphan, Phenylephrine, and Diphenhydramine?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

  • Dizziness.
  • Feeling nervous and excitable.
  • Not able to sleep.
  • Feeling sleepy.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

How do I store and/or throw out Acetaminophen, Dextromethorphan, Phenylephrine, and Diphenhydramine?

  • Store at room temperature.
  • Protect from heat.
  • Store in a dry place. Do not store in a bathroom.
  • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
  • Check with your pharmacist about how to throw out unused drugs.
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