Acetylcholine

Name: Acetylcholine

What are some things I need to know or do while I take Acetylcholine?

  • Tell all of your health care providers that you take acetylcholine. This includes your doctors, nurses, pharmacists, and dentists.
  • Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this medicine while you are pregnant.
  • Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.

If OVERDOSE is suspected

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Dosing Adult

Ophthalmic surgery: Intraocular: Usual dosage: 0.5 to 2 mL

Dosing Hepatic Impairment

There are no dosage adjustments provided in the manufacturer's labeling.

Drug Interactions

Acetylcholinesterase Inhibitors: May enhance the adverse/toxic effect of Cholinergic Agonists. Monitor therapy

Beta-Blockers: May enhance the adverse/toxic effect of Cholinergic Agonists. Of particular concern are the potential for cardiac conduction abnormalities and bronchoconstriction. Management: Administer these agents in combination with caution, and monitor for conduction disturbances. Avoid methacholine with any beta blocker due to the potential for additive bronchoconstriction. Monitor therapy

Adverse Reactions

Frequency not defined.

Cardiovascular: Bradycardia, flushing, hypotension

Dermatologic: Diaphoresis

Ophthalmic: Cloudy vision, corneal decompensation, corneal edema

Respiratory: Dyspnea

Warnings

Cautions

Use reconstituted solution immediately; aqueous solution unstable

Instill gently; forceful jet may rupture the hyaloid, cause vitreous loss, or traumatize/perforate iris

Systemic effects (rare) can cause problems for patients with asthma, acute heart failure, GI spasm, peptic ulcer disease, urinary tract obstruction, acute heart failure, and hyperthyroidism

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your child's doctor or get medical help if your child has any side effects that bother your child or do not go away.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

For Healthcare Professionals

Applies to acetylcholine ophthalmic: compounding powder, intraocular powder for reconstitution

General

The most commonly reported side effects were corneal edema, corneal clouding, and corneal decompensation.[Ref]

Cardiovascular

Rare (less than 0.1%): Bradycardia, hypotension, flushing[Ref]

Ocular

Uncommon (0.1% to 1%): Corneal edema, corneal clouding, corneal decompensation[Ref]

Respiratory

Rare (less than 0.1%): Breathing difficulties[Ref]

Dermatologic

Rare (less than 0.1%): Sweating[Ref]

Some side effects of acetylcholine ophthalmic may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Acetylcholine ophthalmic Breastfeeding Warnings

Use is not recommended. Excreted into human milk: Unknown Excreted into animal milk: Data not available Comments: The effects in the nursing infant are unknown.

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