Acyclovir and Hydrocortisone

Name: Acyclovir and Hydrocortisone

How is this medicine (Acyclovir and Hydrocortisone) best taken?

Use acyclovir and hydrocortisone as ordered by your doctor. Read all information given to you. Follow all instructions closely.

  • Use as you have been told, even if your signs get better.
  • Do not take this medicine by mouth. Use on your skin only. Keep out of your mouth, nose, and eyes (may burn).
  • Wash your hands before and after use.
  • Clean affected part before use. Make sure to dry well.
  • Use a rubber glove to put on the ointment. This helps to prevent the spread of infection.
  • Put a thin layer on the affected skin and rub in gently.
  • Use at the first sign of a cold sore.
  • Do not use coverings (bandages, dressings, make-up) unless told to do so by the doctor.

What do I do if I miss a dose?

  • Put on a missed dose as soon as you think about it.
  • If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
  • Do not put on 2 doses or extra doses.


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Index Terms

  • Acyclovir/Hydrocortisone
  • Hydrocortisone and Acyclovir
  • ME-609
  • Xerclear

Use Labeled Indications

Herpes labialis: Treatment of recurrent herpes labialis (cold sores) in children ≥6 years and adults.

Dosing Renal Impairment

There are no dosage adjustments provided in the manufacturer’s labeling.


Store at 20°C to 25°C (68°F to 77°F); excursions permitted to 15°C to 30°C (59°F to 86°F); do not freeze.

Adverse Reactions

<1% (Limited to important or life-threatening): Allergic contact sensitivity, application site reaction, burning sensation of skin, contact dermatitis (when applied under occlusion), dyschromia, erythema, exfoliation of skin, tingling of skin, xeroderma

Patient Education

• Discuss specific use of drug and side effects with patient as it relates to treatment. (HCAHPS: During this hospital stay, were you given any medicine that you had not taken before? Before giving you any new medicine, how often did hospital staff tell you what the medicine was for? How often did hospital staff describe possible side effects in a way you could understand?)

• Patient may experience bad taste, dry skin, burning, skin tingling, or skin discoloration. Have patient report immediately to prescriber severe skin irritation (HCAHPS).

• Educate patient about signs of a significant reaction (eg, wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat). Note: This is not a comprehensive list of all side effects. Patient should consult prescriber for additional questions.

Intended Use and Disclaimer: Should not be printed and given to patients. This information is intended to serve as a concise initial reference for healthcare professionals to use when discussing medications with a patient. You must ultimately rely on your own discretion, experience and judgment in diagnosing, treating and advising patients.