Acyclovir (Systemic)

Name: Acyclovir (Systemic)

Brand Names U.S.

  • Zovirax

Special Populations Elderly

Increased plasma concentrations.

Dosing Geriatric

Refer to adult dosing.

Dosing Obesity

Obese patients should be dosed using ideal body weight.


Oral: May be administered with or without food.

IV: Avoid rapid infusion; infuse over 1 hour to prevent renal damage; maintain adequate hydration of patient; check for phlebitis and rotate infusion sites. Avoid IM or SubQ administration.

Dietary Considerations

May be taken with or without food. Some products may contain sodium.


Capsule, oral suspension, tablet: Store at controlled room temperature of 15°C to 25°C (59°F to 77°F); protect from capsule and tablet from moisture.

Injection: Store powder at controlled room temperature of 15°C to 25°C (59°F to 77°F). Reconstituted solutions remain stable for 12 hours at room temperature. Do not refrigerate reconstituted solutions or solutions diluted for infusion as they may precipitate. Once diluted for infusion with NS or D5W, use within 24 hours.

Monitoring Parameters

Urinalysis, BUN, serum creatinine, liver enzymes, CBC