Adagen

Call your doctor for instructions if you miss a dose of pegademase bovine.

Give this medicine as ordered by your child's doctor. Read all information given to you. Follow all instructions closely.

• It is given as a shot into a muscle.

What do I do if I miss a dose?

• Call your child's doctor to find out what to do.

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

There is no evidence to support the safety and efficacy of Adagen® (pegademase bovine) Injection as preparatory or support therapy for bone marrow transplantation. Since Adagen® (pegademase bovine) Injection is administered by intramuscular injection, it should be used with caution in patients with thrombocytopenia and should not be used if thrombocytopenia is severe.

Frequency Not Defined

Hematologic events: Hemolytic anemia, autoimmune hemolytic anemia, thrombocythemia, thrombocytopenia and autoimmune thrombocytopenia

Dermatological events: Injection site erythema, urticaria

Lymphomas

Headache