Name: Adoxa

Adoxa Drug Class

Adoxa is part of the drug class:


Side Effects of Adoxa


Serious side effects have been reported with doxycycline. See “Doxycycline Precautions” section.

Common side effects of doxycycline include:

  • nausea
  • vomiting
  • diarrhea
  • itching of the rectum or vagina
  • sore mouth
  • increased sensitivity to sunlight and ultraviolet light
  • mild rash

This is not a complete list of doxycycline side effects.  Ask your doctor or pharmacist for more information.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Adoxa Precautions


Serious side effects have been reported with doxycycline including:

  • Hypersensitivity reaction:  An allergic reaction is possible with doxycycline.  Tell your doctor if you are allergic to doxycycline (Doryx and Oracea), minocycline (Solodyn), or other tetracycline antibiotics.  Tell your doctor if you are allergic to sulfites and will be taking the syrup form of doxycycline.  Symptoms of an allergic reaction include:
    • hives
    • difficulty breathing or swallowing
    • rash
    • itching
    • fatigue
    • confusion
  • Photosensitivity/Phototoxicity:  Doxycycline may increase your sensitivity to sunlight, ultraviolet light from tanning beds, and sunburns. Avoid prolonged exposure to sunlight and wear protective clothing.
  • Tooth discoloration during childhood development:  Tetracycline antibiotics including doxycycline can discolor the tooth enamel of children under the age of 8 and of fetuses in the last half of pregnancy.
  • Decreased effectiveness of oral contraceptives (birth control): Talk to your doctor about methods to prevent pregnancy while taking doxycycline.
  • Overgrowth of bacteria resistant to doxycycline. This can lead to severe infections if not identified and addressed upon occurrence. 

If you are taking doxycycline to prevent malaria, you should know:

  • that no present-day antimalarial agent, including doxycycline, guarantees protection against malaria.
  • to avoid being bitten by mosquitoes by using personal protective measures that help avoid contact with mosquitoes, especially from dusk to dawn (e.g., staying in well-screened areas, using mosquito nets, covering the body with clothing, and using an effective insect repellent).
  • taking doxycycline to prevent malaria:
    •  should begin 1 to 2 days before travel to the malarious area.
    •  should be continued daily while in the malarious area and after leaving the malarious area.
    •  should be continued for 4 further weeks to avoid development of malaria after returning from an endemic area.
    •  should not exceed 4 months.


Inform MD

Before taking doxycycline, tell your doctor about all your medical conditions. Especially tell your doctor if you:

  • have had an allergic reaction to doxycycline (Doryx and Oracea), or other tetracycline antibiotics such as minocycline (Solodyn)
  • take anticoagulants (blood thinners), carbamazepine (Tegretol), phenytoin (Dilantin), vitamins, oral contraceptives, or antacids
  • have kidney or liver disease
  • have diabetes
  • are pregnant or breastfeeding

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Adoxa Dosage

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

  • the condition being treated
  • other medical conditions you have
  • other medications you are taking
  • how you respond to this medication
  • your weight
  • your height
  • your age
  • your gender


  • Take doxycycline exactly as prescribed.  Follow the directions on your prescription label carefully.
  • Your doctor will determine the appropriate dosage and schedule of doxycycline depending on the type and severity of your infection, as well as your age.
  • The range of doses for all forms of doxycycline is 100 to 200 mg a day, with a maximum daily dose of 600 mg.
  • When taking doxycycline for the prevention of malaria, you should start taking the drug 1 to 2 days before traveling to an area with malaria. Continue taking doxycycline for 4 weeks after leaving the area with malaria, but not for longer than 4 months total.
  • When being used in a dental setting for the treatment of periodontitis, the amount of doxycycline that is applied per administration is 50 mg. 


  • The recommended dosing range for doxycycline injectable in adults is 100 to 300 mg per day.

What is Adoxa (doxycycline)?

Doxycycline is a tetracycline antibiotic that fights bacteria in the body.

Doxycycline is used to treat many different bacterial infections, such as acne, urinary tract infections, intestinal infections, eye infections, gonorrhea, chlamydia, periodontitis (gum disease), and others.

Doxycycline is also used to treat blemishes, bumps, and acne-like lesions caused by rosacea. Doxycycline will not treat facial redness caused by rosacea.

Some forms of doxycycline are used to prevent malaria, to treat anthrax, or to treat infections caused by mites, ticks, or lice.

Doxycycline may also be used for purposes not listed in this medication guide.

What is the most important information I should know about Adoxa (doxycycline)?

You should not take this medicine if you are allergic to any tetracycline antibiotic.

Children younger than 8 years old should use doxycycline only in cases of severe or life-threatening conditions. This medicine can cause permanent yellowing or graying of the teeth in children

Using doxycycline during pregnancy could harm the unborn baby or cause permanent tooth discoloration later in the baby's life.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Uses For Adoxa

Doxycycline is used to treat bacterial infections in many different parts of the body. It is also used to treat pimples and abscesses (usually on the face) that are caused by rosacea, also known as acne rosacea or adult acne.

Doxycycline delayed-release tablets and tablets are also used to prevent malaria and treat anthrax infection after possible exposure and other conditions as determined by your doctor.

Doxycycline belongs to the class of medicines known as tetracycline antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

This medicine is available only with your doctor's prescription.

Adverse Reactions

Due to oral doxycycline’s virtually complete absorption, side effects to the lower bowel, particularly diarrhea, have been infrequent. The following adverse reactions have been observed in patients receiving tetracyclines:

Gastrointestinal: Anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, and inflammatory lesions (with monilial overgrowth) in the anogenital region. Hepatotoxicity has been reported(b)(4).These reactions have been caused by both the oral and parenteral administration of tetracyclines. Rare instances of esophagitis and esophageal ulcerations have been reported in patients receiving capsule and tablet forms of drugs in the tetracycline class. Most of these patients took medications immediately before going to bed. (See DOSAGE AND ADMINISTRATION.)

Skin: Maculopapular and erythematous rashes Stevens-Johnson syndrome, toxic epidermal necrolysis and erythema multiforme have been reported. Exfoliative dermatitis has been reported but is uncommon. Photosensitivity is discussed above. (See WARNINGS.)

Renal toxicity: Rise in BUN has been reported and is apparently dose related. (See WARNINGS.)

Hypersensitivity reactions: Urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, serum sickness, pericarditis, and exacerbation of systemic lupus erythematosus.

Blood: Hemolytic anemia, thrombocytopenia, neutropenia, and eosinophilia have been reported with tetracyclines.

Other: Bulging fontanels in infants and intracranial hypertension in adults. (See PRECAUTIONS-General.)

When given over prolonged periods, tetracyclines have been reported to produce brown-black microscopic discoloration of the thyroid gland. No abnormalities of thyroid function are known to occur.