Afrin

Name: Afrin

What Is Oxymetazoline Nasal?

Oxymetazoline is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).

Oxymetazoline nasal (for the nose) is for temporary relief of nasal congestion (stuffy nose) caused by allergies or the common cold.

Oxymetazoline nasal may also be used for purposes not listed in this medication guide.

Oxymetazoline nasal (for the nose) is used for temporary relief of nasal congestion caused by allergies or the common cold.

Stop using this medicine and call your doctor at once if you have ongoing or worsening symptoms, or if you have severe burning or stinging in your nose after using the nasal spray

You should not use oxymetazoline nasal if you are allergic to it.

Ask a doctor or pharmacist if it is safe for you to take this medicine if you have other medical conditions, especially:

  • heart disease, high blood pressure, coronary artery disease;
  • diabetes;
  • a thyroid disorder; or
  • enlarged prostate or urination problems.

FDA pregnancy category C. It is not known whether oxymetazoline nasal will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether oxymetazoline nasal passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Oxymetazoline Nasal Interactions

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Ask a doctor or pharmacist if it is safe for you to use oxymetazoline nasal if you are also using any of the following drugs:

  • an antidepressant--amitriptyline, clomipramine, desipramine, doxepin, imipramine, nortriptyline;
  • ergot medicine--ergotamine, dihydroergotamine, ergonovine, methylergonovine; or
  • an MAO inhibitor--isocarboxazid, linezolid, phenelzine, rasagiline, selegiline, tranylcypromine.

This list is not complete and other drugs may interact with oxymetazoline nasal. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Manufacturer

  • MSD Consumer Care, Inc.

  • Schering Plough Healthcare Products Inc.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

Proper Use of oxymetazoline

This section provides information on the proper use of a number of products that contain oxymetazoline. It may not be specific to Afrin. Please read with care.

To use the nose drops:

  • Blow your nose gently. Tilt the head back while standing or sitting up, or lie down on a bed and hang the head over the side. Place the drops into each nostril and keep the head tilted back for a few minutes to allow the medicine to spread throughout the nose.
  • Rinse the dropper with hot water and dry with a clean tissue. Replace the cap right after use.
  • To avoid spreading a cold or infection, do not use the container for more than one person and throw the container away after your cold is better.

To use the nose spray:

  • Blow your nose gently. With the head upright, spray the medicine into each nostril. Sniff briskly while squeezing the bottle quickly and firmly. If needed, blow the nose gently again and repeat the spray process until the total dose is used.
  • Rinse the tip of the spray bottle with hot water, taking care not to suck water into the bottle, and dry with a clean tissue. Replace the cap right after use.
  • To avoid spreading a cold or infection, do not use the container for more than one person and throw the container away after your cold is better.

Use this medicine only as directed. Do not use more of it, do not use it more often, and do not use it for longer than 3 days without checking with your doctor. To do so may make your runny or stuffy nose worse and may increase the chance of side effects.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For nasal dosage form (nose drops or spray):
    • For nasal congestion or stuffiness:
      • Adults and children 6 years of age and older—Use 2 or 3 drops or sprays of 0.05% solution in each nostril every ten to twelve hours. Do not use more than two times in twenty four hours.
      • Children up to 6 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

For the Consumer

Applies to oxymetazoline nasal: nasal solution, nasal spray

Along with its needed effects, oxymetazoline nasal (the active ingredient contained in Afrin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking oxymetazoline nasal:

  • Blurred vision
  • fast, irregular, or pounding heartbeat
  • headache, dizziness, drowsiness, or lightheadedness
  • high blood pressure
  • increase in runny or stuffy nose
  • nervousness
  • trembling
  • trouble in sleeping
  • weakness

Some side effects of oxymetazoline nasal may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

  • Burning, dryness, or stinging inside of nose
  • sneezing

For Healthcare Professionals

Applies to oxymetazoline nasal: nasal solution, nasal spray

Cardiovascular

Very rare (less than 0.01%): Tachycardia, palpitations, increased blood pressure[Ref]

Gastrointestinal

Very rare (less than 0.01%): Nausea[Ref]

General

The most commonly reported side effects were discomfort or irritation in the nose, mouth or throat, and sneezing.[Ref]

Nervous system

Very rare (less than 0.01%): Insomnia, nervousness, tremor, anxiety, restlessness, irritability, headache[Ref]

Ocular

Rare (less than 0.1%): Eye irritation, dryness, discomfort/redness[Ref]

Respiratory

Rare (less than 0.1%): Discomfort or irritation in the nose, mouth or throat, sneezing
Frequency not reported: Rhinitis medicamentosa (after prolonged or heavy use)[Ref]

Some side effects of Afrin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Usual Adult Dose for Nasal Congestion

2 or 3 sprays in each nostril not more often than every 10 to 12 hours

Comments:
-Do not exceed 2 doses in any 24-hour period.

Uses: Temporary relief of nasal congestion due to common cold, hay fever, and
upper respiratory allergies

Liver Dose Adjustments

Data not available

Oxymetazoline nasal Breastfeeding Warnings

Use should be avoided. Excreted into human milk: Data not available Excreted into animal milk: Data not available Comments: The effects in the nursing infant are unknown.

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