Alclometasone Dipropionate

Name: Alclometasone Dipropionate

Introduction

A synthetic corticosteroid.1 2 12 d

Uses for Alclometasone Dipropionate

Corticosteroid-responsive Dermatoses

Relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.1 4 5 6 7 8 9 10 11 13 14 17 18 d

Generally most effective in acute or chronic dermatoses (e.g., seborrheic or atopic dermatitis, localized neurodermatitis, anogenital pruritus, psoriasis, late phase of allergic contact dermatitis, inflammatory phase of xerosis).b

Topical therapy generally preferred over systemic therapy; fewer associated adverse systemic effects.b

Topical therapy generally only controls manifestations of dermatoses; eliminate cause if possible.b

Topical efficacy may be increased by using a higher concentration or occlusive dressing therapy. (See Administration with Occlusive Dressing under Dosage and Administration.)b

Response may vary from one topical corticosteroid preparation to another.b

Anti-inflammatory activity may vary considerably depending on the vehicle, drug concentration, site of application, disease, and individual patient.b

Manufacturers state that alclometasone should not be used for the treatment of acne, rosacea, or perioral dermatitis.22 23

Alclometasone dipropionate 0.05% cream and ointment are considered to have low-to-medium range potency.b c d

Interactions for Alclometasone Dipropionate

Specific Drugs and Laboratory Tests

Drug or Test

Interaction

Nitroblue-tetrazolium test for bacterial infection

Concurrent use of corticosteroids reportedly may result in false-negative resultsb

Stability

Storage

Topical

Cream and ointment: 2–30°C.1 Some manufacturers state 20–25°C.d Consult product information for specific recommendations.

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Alclometasone Dipropionate

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Topical

Cream

0.05%*

Alclometasone Dipropionate Cream (with propylene glycol)

Fougera, Taro

Aclovate (with propylene glycol)

GlaxoSmithKline

Ointment

0.05%*

Alclometasone Dipropionate Ointment

Fougera, Taro

Aclovate (with propylene glycol)

GlaxoSmithKline

(web3)