Alitretinoin Topical

Name: Alitretinoin Topical

Commonly used brand name(s)

In the U.S.

  • Panretin

Available Dosage Forms:

  • Gel/Jelly

Therapeutic Class: Dermatological Agent

Chemical Class: Retinoid

Proper Use of alitretinoin

Avoid the use of occlusive dressings


The dose of alitretinoin will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of alitretinoin. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For topical dosage form (gel):
    • For cutaneous Kaposi's sarcoma:
      • Adults—Apply a generous amount to the affected area of the skin two times day, or as directed by your doctor, and allow to dry for three to five minutes before covering with clothing.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of alitretinoin, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Consumer Information Use and Disclaimer

  • If your symptoms or health problems do not get better or if they become worse, call your doctor.
  • Do not share your drugs with others and do not take anyone else's drugs.
  • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
  • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
  • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about alitretinoin (topical), please talk with your doctor, nurse, pharmacist, or other health care provider.
  • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about alitretinoin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using alitretinoin.

Review Date: October 4, 2017


(a li TRET i noyn)


Apply sufficient gel to cover lesion(s) with a generous coating; allow gel to dry 3-5 minutes after application before covering with clothing. Do not use occlusive dressings. Avoid applying gel to normal skin surrounding lesions. Do not apply to any lesions on or near mucosal surfaces.

Adverse Reactions


Central nervous system: Pain (≤34%), paresthesia (3% to 22%)

Dermatologic: Skin rash (25% to 77%), pruritus (8% to 11%)

1% to 10%:

Cardiovascular: Edema (3% to 8%)

Dermatologic: Exfoliative dermatitis (3% to 9%), dermatological disease (≤8%)

What should I avoid while using alitretinoin topical?

Avoid getting this medication in your eyes, nose, mouth, rectum, or vagina. If this does happen, rinse with water.

Do not use insect repellents or other products that contain DEET (N,N-diethyl-m-toluamide) while using alitretinoin topical.

Avoid exposure to sunlight or tanning beds while using this medicine. Alitretinoin can make you sunburn more easily. Wear protective clothing when you are outdoors.

Adverse Effects


Rash (25-77%)

Pruritus (8-11%)

Paresthesia (3-22%)

Pain (<34%)

Pruritus (11%)


Exfoliative dermatitis (3-9%)

Edema (3-8%)

Skin disorders (8%)

Paresthesia (3%)