Name: Aloxi

Other uses for this medicine

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before receiving palonosetron injection,

  • tell your doctor and pharmacist if you are allergic to palonosetron, alosetron (Lotronex), dolasetron (Anzemet), granisetron (Kytril, Sancuso), ondansetron (Zofran), or any other medications, or any of the ingredients in palonosetron injection. Ask your pharmacist or check the manufacturer's patient information for a list of the ingredients.
  • tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. Be sure to mention any of the following: fentanyl (Abstral, Actiq, Duragesic, Fentora, Lazanda, Onsolis, Subsys), lithium (Lithobid); medications to treat migraines such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), and zolmitriptan (Zomig); methylene blue; mirtazapine (Remeron); monoamine oxidase (MAO) inhibitors including isocarboxazid (Marplan), linezolid (Zyvox), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate); selective serotonin reuptake inhibitors (SSRIs) such as citalopram (Celexa), escitalopram (Lexapro), fluoxetine (Prozac, Sarafem, in Symbyax), fluvoxamine (Luvox), paroxetine (Brisdelle, Paxil, Pexeva), and sertraline (Zoloft); and tramadol (Conzip, Ultram, in Ultracet). Your doctor may need to change the doses of your medications or monitor you more carefully for side effects.
  • tell your doctor if you have or have ever had any medical condition.
  • tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while receiving palonosetron injection, call your doctor.

Aloxi Precautions

Serious allergic reactions. Serious allergic reactions can happen with Aloxi. Tell your doctor if you experience redness or swelling of the skin, itching, chest discomfort or shortness of breath.

Aloxi Usage

Aloxi is given in your vein by I.V. (intravenous) injection. It is only given to you by a healthcare provider in a hospital or clinic. Aloxi is usually injected into your vein about 30 minutes before you get your anti-cancer medicine (chemotherapy) or immediately before anesthesia for surgery.



Hypersensitivity to drug, other selective 5-HT3 receptor antagonists (eg, granisetron), or any other component

Coadministration with apomorphine; combination reported to cause profound hypotension and loss of consciousness


Use caution in patients with congenital long QT syndrome or other factors that may prolong QT interval

Serotonin syndrome reported with 5-HT3 receptor antagonists alone but particularly with concomitant use of serotonergic drugs including SSRIs, SNRIs, MAO inhibitors, lithium, tramadol, methylene blue IV, and mirtazapine

Hypersensitivity reactions, including anaphylaxis, reported with or without known hypersensitivity to other 5-HT3 receptor antagonists

For chemotherapy, the drug should follow a specific schedule, and not be administered as needed

Drug is not recommended in PONV if expectation for nausea or vomiting is very small; use only if the expectation is low or it is essential to avoid nausea and vomiting in the postoperative period


Antiemetic; selective, second-generation inhibitor of type 3 serotonergic (5-HT3) receptors.1 17 28

Uses For Aloxi

Palonosetron injection is used to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy). It is also used to prevent nausea and vomiting that may occur after surgery. Palonosetron works by blocking the signals to the brain that cause nausea and vomiting.

This medicine is to be given only by or under the direct supervision of your doctor.

Proper Use of Aloxi

You will receive this medicine while you or your child are in a hospital or cancer treatment center. A nurse or other trained health professional will give you or your child this medicine. This medicine is given through a needle placed in one of your veins.

This medicine is usually given about 30 minutes before the start of chemotherapy or right before you or your child receives anesthetic medicine for surgery.

This medicine should come with a patient information leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions.

If OVERDOSE is suspected

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Aloxi?

  • If you need to store Aloxi at home, talk with your doctor, nurse, or pharmacist about how to store it.

Where can i get more information?

Your pharmacist can provide more information about palonosetron.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

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Dosing & Uses

Dosage Forms & Strengths

injectable solution: single-use vials

  • 0.05mg/mL

Prevention of Chemotherapy-induced Nausea & Vomiting

Indicated for prevention of acute N/V associated with moderately or highly emetogenic chemotherapeutic agents; also for delayed N/V associated moderately emetogenic chemotherapeutic agents

0.25 mg IV over 30 seconds x1, beginning 30 minutes before chemotherapy

Prevention of Postoperative Nausea & Vomiting

Indicated for prevention of PONV following surgery; efficacy beyond 24 hr has not been demonstrated

0.075 mg IV infused over 10 seconds immediately before anesthesia

Dosage Modifications

Renal or hepatic impairment: Dose adjustment not necessary

Dosage Forms & Strengths

injectable solution: single-use vials

  • 0.05mg/mL

Prevention of Chemotherapy-induced Nausea & Vomiting

Indicated for prevention of acute N/V associated with initial and repeat courses of emetogenic cancer chemotherapy, including highly emetogenic cancer chemotherapy

Adverse Effects


Prolonged QT interval (up to 5%)









LFT's increased