Aluminum chloride hexahydrate topical

Name: Aluminum chloride hexahydrate topical

What Is Drysol?

Drysol is the brand name of a topical treatment that uses aluminum chloride hexahydrate and anhydrous ethyl alcohol. It's used to treat excessive sweating.

The medicine is an antiperspirant. It works by closing your sweat ducts.

Drysol can be used on areas such as the underarms, scalp, hands, and feet.

Person & Covey, Inc. manufactures the medicine.

Drysol Warnings

Talk to your doctor before using Drysol if you have a serious medical condition or are allergic to ingredients in the product.

Also, let your doctor know if you're taking Antabuse (disulfiram) before using Drysol.

Don't apply any other deodorant or antiperspirant while using Drysol without first talking to your doctor.

Avoid getting Drysol in your eyes, mouth, or nose, or on your lips. If this happens, wash the area thoroughly with water.

Don't use this medicine near an open flame. Drysol contains alcohol and is flammable.

Tell your healthcare provider if your symptoms don't improve, or worsen, while using this product.

Don't use this medicine on irritated or broken skin. Also, avoid using Drysol on areas that have recently been shaved.

Drysol may stain certain fabrics or metals. Keep the medicine away from surfaces that you don't want to stain.

Never share Drysol with others, even if they have the same symptoms as you.

Pregnancy and Drysol

It's not known whether Drysol can harm an unborn baby.

Let your doctor know if you're pregnant, or might become pregnant while using this product.

It's also not known whether Drysol passes into breast milk or could hurt a breastfeeding baby.

Talk to your doctor before breastfeeding while using this medicine.

Drysol Dosage

Drysol comes in different formulations to treat different areas of the body.

The medicine is usually used for two or three nights, until you notice results. After that, it's typically applied once or twice a week, or as directed by your doctor.

Apply Drysol at bedtime. For best results, the medicine should be left on your skin for six to eight hours.

Follow the instructions on the product label carefully. Don't apply more or less Drysol than is recommended.

Be sure to use Drysol on skin that's completely dry. You may need to dry your skin with a hairdryer first.

After applying Drysol on your underarms, you may want to wear a T-shirt to keep the medicine from rubbing off on your bedsheets.

If you're using Drysol on your hands or feet, you can wrap the areas in plastic and cover them with cotton gloves or socks. Don't tape the plastic onto your skin.

If you're using Drysol on your scalp, you can wear a plastic shower cap to keep the medicine from rubbing off on your bedsheets.

In the morning, wash or shampoo the treated areas and dry them with a towel.

Drysol Overdose

Drysol may be harmful if swallowed.

If you accidently swallow this medicine or suspect an overdose, contact a poison control center or emergency room.

You can get in touch with a poison control center at 800-222-1222.

Missed Dose of Drysol

If you miss a dose of Drysol and use it regularly, skip the missed dose and return to your regular dosing schedule.

Don't apply extra Drysol to make up for a missed dose.

What is the most important information I should know about aluminum chloride hexahydrate?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What happens if I miss a dose?

Skip the missed dose and use the medicine the following night. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

An overdose of aluminum chloride hexahydrate is not expected to be dangerous. Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if anyone has accidentally swallowed the medication.

What should I avoid while using aluminum chloride hexahydrate?

Do not apply any other deodorants or antiperspirants while you are using aluminum chloride hexahydrate.

Aluminum chloride hexahydrate contains alcohol, which can cause slight burning or stinging when you apply the medicine. Do not use on irritated or broken skin, or skin that has recently been shaved.

Avoid getting this medicine in your eyes, mouth, and nose, or on your lips. If it does get into any of these areas, wash with water.

Aluminum chloride hexahydrate can stain certain types of fabric or metals that it comes in contact with. Avoid getting the medicine on surfaces you do not want to stain.

Do not share this medicine with another person, even if they have the same symptoms you have.


  • Pathophysiology of focal hyperHIDrosis is poorly understood.8 10

  • Eccrine (sweat) glands are distributed over nearly the entire body surface with high concentrations in palms, soles, and forehead.8 These glands are innervated by cholinergic fibers of the sympathetic nervous system.8 9 10

  • Since patients with focal hyperHIDrosis do not have any histopathologic changes in sweat glands or in their numbers, it has been suggested that a complex dysfunction of the sympathetic nervous system is likely to contribute to hyperHIDrosis.8 10

  • Mechanically blocks eccrine sweat gland ducts,5 6 7 9 10 12 13 14 possibly by forming aluminum ion precipitate complexes within the acrosyringium (most superficial) portion of eccrine glands.12

  • Long-term (≥6 months) use appears to cause dilation and atrophy of secretory cells within eccrine sweat glands.5 12 13 14

  • Does not appear to affect apocrine glands.12


This medicine may be harmful if swallowed. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.


Do not share this medication with others.

Missed Dose

If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.


Store at room temperature between 59-86 degrees F (15-30 degrees C) away from heat. Do not use near an open flame. Keep container tightly closed. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.Information last revised July 2016. Copyright(c) 2016 First Databank, Inc.