Aminohippurate Sodium

Name: Aminohippurate Sodium

Clinical pharmacology

PAH is filtered by the glomeruli and is actively secreted by the proximal tubules. At low plasma concentrations (1.0 to 2.0 mg/100 mL), an average of 90 percent of PAH is cleared by the kidneys from the renal blood stream in a single circulation. It is ideally suited for measurement of ERPF since it has a high clearance, is essentially nontoxic at the plasma concentrations reached with recommended doses, and its analytical determination is relatively simple and accurate.

PAH is also used to measure the functional capacity of the renal tubular secretory mechanism or transport maximum (TmPAH). This is accomplished by elevating the plasma concentration to levels (40-60 mg/100 mL) sufficient to saturate the maximal capacity of the tubular cells to secrete PAH.

Inulin clearance is generally measured during TmPAH determinations since glomerular filtration rate (GFR) must be known before calculations of secretory Tm measurements can be done (see DOSAGE AND ADMINISTRATION, Calculations).

Aminohippurate Sodium Description

Aminohippurate Sodium1 is an agent to measure effective renal plasma flow (ERPF). It is the sodium salt of para-aminohippuric acid, commonly abbreviated “PAH”. It is water soluble, lipid-insoluble, and has a pKa of 3.83. The empirical formula of the anhydrous salt is C9H9N2NaO3 and its structural formula is:

It is provided as a sterile, non-preserved 20 percent aqueous solution for injection, with a pH of 6.7 to 7.6. Each 10 mL contains: Aminohippurate Sodium 2 g. Inactive ingredients: Sodium hydroxide to adjust pH, water for injection, q.s.


Formerly referred to as Sodium para-Aminohippurate.

Indications and Usage for Aminohippurate Sodium

Estimation of effective renal plasma flow.

Measurement of the functional capacity of the renal tubular secretory mechanism.

This is a representative sample of the packaging. Please see How Supplied section for a complete list of available packaging. PRINCIPAL DISPLAY PANEL - Carton - 10 mL Single Dose Vial

NDC 0006-3395-11


Aminohippurate Sodium

2 g in 10 mL
(20% solution)


Rx only

Merck Sharp & Dohme Corp.,
a subsidiary of
Whitehouse Station, NJ 08889, USA

Aminohippurate Sodium  PAH
Aminohippurate Sodium injection, solution
Product Information
Product Type HUMAN PRESCRIPTION DRUG LABEL Item Code (Source) NDC:0006-3395
Route of Administration INTRAVENOUS DEA Schedule     
Active Ingredient/Active Moiety
Ingredient Name Basis of Strength Strength
Aminohippurate Sodium (AMINOHIPPURIC ACID) Aminohippurate Sodium 2 g  in 10 mL
Inactive Ingredients
Ingredient Name Strength
Product Characteristics
Color YELLOW, BROWN (colorless to yellow/brown) Score     
Shape Size
Flavor Imprint Code
# Item Code Package Description
1 NDC:0006-3395-11 1 VIAL, SINGLE-DOSE (VIAL) in 1 CARTON
1 10 mL in 1 VIAL, SINGLE-DOSE
Marketing Information
Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date
NDA NDA005619 12/30/1944
Labeler - Merck Sharp & Dohme Corp. (001317064)
Name Address ID/FEI Operations
Merck Sharp & Dohme Corp. 002387926 MANUFACTURE
Revised: 01/2011   Merck Sharp & Dohme Corp.


Consult your pharmacist.

How to use Aminohippurate Sodium Powder

Consult your pharmacist.

Side Effects

Consult your pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.


Consult your pharmacist.


Consult your pharmacist.

Keep a list of all your medications with you, and share the list with your doctor and pharmacist.


If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.


No monograph available at this time.

Missed Dose

Consult your pharmacist.


Consult your pharmacist.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised July 2016. Copyright(c) 2016 First Databank, Inc.