Amphetamine

Name: Amphetamine

What Is Amphetamine?

Amphetamine is a central nervous system stimulant that affects chemicals in the brain and nerves that contribute to hyperactivity and impulse control.

Amphetamine is used to treat attention deficit hyperactivity disorder (ADHD).

The Evekeo brand of amphetamine is used to treat ADHD and also narcolepsy. Evekeo is sometimes used to treat obesity in people who have not lost weight with diets or other treatments.

Amphetamine may also be used for purposes not listed in this medication guide.

Do not use amphetamine if you have used an MAO inhibitor in the past 14 days, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, or tranylcypromine.

Amphetamine may be habit-forming. Never share amphetamine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law.

Using this medicine improperly can cause death or serious side effects on the heart.

Do not use amphetamine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

You should not use amphetamine if you are allergic to any stimulant medicine, or if you have:

  • moderate to severe high blood pressure;
  • heart disease or coronary artery disease (hardened arteries);
  • overactive thyroid;
  • severe anxiety, tension, or agitation (stimulant medicine can make these symptoms worse); or
  • a history of drug or alcohol addiction.

Some stimulants have caused sudden death in certain people. Tell your doctor if you have:

  • heart problems or a congenital heart defect;
  • high blood pressure; or
  • a family history of heart disease or sudden death.

To make sure this medicine is safe for you, tell your doctor if you or anyone in your family has ever had:

  • depression, mental illness, bipolar disorder, psychosis, or suicidal thoughts or actions;
  • motor tics (muscle twitches) or Tourette's syndrome;
  • kidney disease;
  • a thyroid disorder;
  • seizures or epilepsy;
  • an abnormal brain wave test (EEG); or
  • blood circulation problems in the hands or feet.

It is not known whether this medicine will harm an unborn baby. However, taking the medicine during pregnancy can cause premature birth, low birth weight, or withdrawal symptoms in the newborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Amphetamine can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Amphetamine is not approved for use by anyone younger than 6 years old.

Amphetamine Dosage

Using this medicine improperly can cause death or serious side effects on the heart.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Amphetamine may be habit-forming. Never share amphetamine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. Selling or giving away this medicine is against the law.

You may take amphetamine with or without food. It is best to take this medicine first thing in the morning.

If your doctor changes your brand, strength, or type of stimulant medicine, your dosage needs may change. Use only the brand of this medicine your doctor has prescribed.

Shake the oral suspension (liquid) well just before you measure a dose. Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.

To take the null (Adzenys XR-ODT):

  • Keep the tablet in its blister pack until you are ready to take it. Open the package and peel back the foil. Do not push a tablet through the foil or you may damage the tablet.
  • Use dry hands to remove the tablet and place it in your mouth.
  • Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing. If desired, you may drink liquid to help swallow the dissolved tablet.

While using this medicine, your doctor will need to check your progress at regular visits. Your heart rate, blood pressure, height and weight may also need to be checked often.

Amphetamine can cause unusual results with certain medical tests. Tell any doctor who treats you that you are using this medicine.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Keep track of the amount of medicine used from each new bottle. Amphetamine is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

Throw away unused or expired amphetamine in a sealed container or bag. Ask your pharmacist where to locate a community pharmaceutical take back disposal program.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of amphetamine could be fatal.

Overdose symptoms may include restlessness, tremor, muscle twitches, rapid breathing, hostility, violence, panic, muscle pain or weakness, and dark colored urine. These symptoms may be followed by depression and tiredness. Other overdose symptoms include nausea, vomiting, diarrhea, stomach pain, fainting, seizure (convulsions), or coma.

Take the missed dose as soon as you remember, but not late in the day or you could have trouble sleeping. Skip the missed dose if it is almost evening. Do not take extra medicine to make up the missed dose.

What should I discuss with my healthcare provider before taking amphetamine?

You should not use amphetamine if you are allergic to any stimulant medicine, or if you have:

  • moderate to severe high blood pressure;

  • overactive thyroid;

  • severe anxiety, tension, or agitation (stimulant medicine can make these symptoms worse); or

  • a history of drug or alcohol addiction.

Do not use amphetamine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Some medicines can interact with amphetamine and cause a serious condition called serotonin syndrome. Be sure your doctor knows if you also take opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. Ask your doctor before making any changes in how or when you take your medications.

Stimulants have caused stroke, heart attack, and sudden death in certain people. Tell your doctor if you have:

  • heart problems or a congenital heart defect;

  • high blood pressure; or

  • a family history of heart disease or sudden death.

To make sure amphetamine is safe for you, tell your doctor if you or anyone in your family has ever had:

  • depression, mental illness, bipolar disorder, psychosis, or suicidal thoughts or actions;

  • problems with drug or alcohol abuse;

  • motor tics (muscle twitches) or Tourette's syndrome;

  • kidney disease;

  • a thyroid disorder;

  • seizures or epilepsy;

  • an abnormal brain wave test (EEG);

  • coronary artery disease (clogged arteries); or

  • blood circulation problems in the hands or feet.

It is not known whether this medicine will harm an unborn baby. However, taking the medicine during pregnancy can cause premature birth, low birth weight, or withdrawal symptoms in the newborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Amphetamine can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Amphetamine is not approved for use by anyone younger than 6 years old.

Proper Use of amphetamine

Take amphetamine exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much is taken, it may become habit-forming. If you feel that the medicine is not working properly after taking it for several weeks, check with your doctor first and do not increase the dose.

amphetamine should come with a Medication Guide. Read and follow the instructions carefully. Ask your doctor if you have any questions.

Amphetamine is used for different conditions and comes in different forms. Make sure you understand how to take your prescribed brand.

It is best to take amphetamine when you wake up in the morning. You may take amphetamine with or without food.

Measure the extended-release oral suspension with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid. Shake the bottle before each use.

If you are using the extended-release oral disintegrating tablet, make sure your hands are dry before you handle the tablet. Do not open the blister pack that contains the tablet until you are ready to take it. Remove the tablet from the blister pack by peeling back the foil, then taking the tablet out. Do not push the tablet through the foil. Place the tablet in your mouth. It should melt quickly.

Dosing

The dose of amphetamine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of amphetamine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (extended-release suspension):
    • For ADHD:
      • Adults and children 6 years of age and older—At first, 2.5 or 5 milligrams (mg) once a day, in the morning. Your doctor may increase your dose as needed. However, the dose is usually not more than 20 mg per day.
      • Children younger than 6 years of age—Use and dose must be determined by your doctor.
  • For oral dosage form (extended release oral disintegrating tablets):
    • For ADHD:
      • Adults—12.5 milligrams (mg) once a day, in the morning.
      • Children 13 to 17 years of age and older—At first, 6.3 mg once a day, in the morning. Your doctor may increase your dose as needed. However, the dose is usually not more than 12.5 mg per day.
      • Children 6 to 12 years of age—At first, 6.3 mg once a day, in the morning. Your doctor may increase your dose as needed. However, the dose is usually not more than 18.8 mg per day.
      • Children younger than 6 years of age—Use and dose must be determined by your doctor.
  • For oral dosage form (tablets):
    • For ADHD:
      • Adults and children 6 years of age and older—At first, 5 milligrams (mg) once or two times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 40 mg per day.
      • Children 3 to 5 years of age—At first, 2.5 mg once a day. Your doctor may increase your dose as needed.
      • Children younger than 3 years of age—Use is not recommended.
    • For narcolepsy:
      • Adults and children 12 years of age and older—At first, 10 milligrams (mg) once a day, in the morning. Your doctor may increase your dose as needed. However, the dose is usually not more than 60 mg per day.
      • Children 6 to 11 years of age—At first, 5 mg once a day, in the morning. Your doctor may increase your dose as needed.
      • Children younger than 6 years of age—Use and dose must be determined by your doctor.
    • For weight loss:
      • Adults and children 12 years of age and older—5 to 10 milligrams (mg) per day, taken 30 to 60 minutes before each meal. Your doctor may increase your dose as needed. However, the dose is usually not more than 30 mg per day.
      • Children younger than 12 years of age—Use is not recommended.

Missed Dose

If you miss a dose of amphetamine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Dosing Geriatric

Refer to adult dosing.

Administration

Oral:

Extended-release orally disintegrating tablet: Administer in the morning with or without food. Do not remove from blister until ready to administer. Using dry hands, peel backing off the blister; do not push tablet through foil. Remove tablet and immediately place on tongue and allow to disintegrate. Swallow with saliva. Do not chew or crush tablet.

Extended-release suspension: Administer in the morning with or without food; use the oral dosing dispenser provided. Administer directly into mouth from dispenser; wash dispenser after each use. Shake bottle well prior to administration.

Immediate-release tablet: Administer with or without food; for short-term adjunct treatment of exogenous obesity, administer 30 to 60 minutes before meals. Administer the first dose on awakening; administer additional doses at intervals of 4 to 6 hours. Avoid late evening dosing.

Adverse Reactions

As reported in children and adults unless otherwise noted.

1% to 10%:

Gastrointestinal: Upper abdominal pain (children: 4%)

Respiratory: Allergic rhinitis (children: 4%), epistaxis (children: 4%)

Frequency not defined:

Cardiovascular: Increased blood pressure, palpitations, Raynaud's phenomenon, tachycardia

Central nervous system: Dizziness, dysphoria, euphoria, exacerbation of Gilles de la Tourette's syndrome, headache, insomnia, overstimulation, psychosis, restlessness, tics (including exacerbation), vocal tics (exacerbation)

Dermatologic: Urticaria

Endocrine & metabolic: Change in libido, growth suppression (children), weight loss (children)

Gastrointestinal: Anorexia, constipation, diarrhea, dysgeusia, gastrointestinal disease, vomiting, xerostomia

Genitourinary: Erectile dysfunction (frequent or prolonged erections), impotence

Neuromuscular & skeletal: Dyskinesia, rhabdomyolysis, tremor

<1%, postmarketing, and/or case reports: Mania, peripheral vascular disease

ALERT U.S. Boxed Warning

Abuse potential (Adzenys XR-ODT, Dyanavel XR, Evekeo):

Amphetamines have a high potential for abuse and dependence. Administration of amphetamines for prolonged periods of time may lead to drug dependence and must be avoided. Assess the risk of abuse prior to prescribing, and monitor for signs of abuse and dependence while on therapy. Particular attention should be paid to the possibility of subjects obtaining amphetamines for non-therapeutic use or distribution to others, and the drugs should be prescribed or dispensed sparingly.

Cardiovascular events (Evekeo):

Misuse of amphetamine may cause sudden death and serious cardiovascular adverse events.

What should I avoid while taking amphetamine?

Avoid drinking alcohol while you are taking this medicine.

Avoid drinking fruit juices or taking vitamin C at the same time you take amphetamine. These can make your body absorb less of the medicine.

Amphetamine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

What other drugs will affect amphetamine?

Ask your doctor before using a stomach acid medicine (including Alka-Seltzer or sodium bicarbonate). Some of these medicines can change the way your body absorbs amphetamine, and may increase side effects.

Many drugs can interact with amphetamine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide. Tell your doctor about all your current medicines and any medicine you start or stop using.

Renal Dose Adjustments

Data not available

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