Amphocin

Name: Amphocin

US Brand Name

  1. Amphocin
  2. Fungizone

Amphocin Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More commonWith intravenous injection
  • Fever and chills
  • headache
  • increased or decreased urination
  • irregular heartbeat
  • muscle cramps or pain
  • nausea
  • pain at the place of injection
  • unusual tiredness or weakness
  • vomiting
Less common or rareWith intravenous injection
  • Blurred or double vision
  • convulsions (seizures)
  • numbness, tingling, pain, or weakness in hands or feet
  • shortness of breath, troubled breathing, wheezing, or tightness in chest
  • skin rash or itching
  • sore throat and fever
  • unusual bleeding or bruising
With spinal injection
  • Blurred vision or any change in vision
  • difficult urination
  • numbness, tingling, pain, or weakness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More commonWith intravenous injection
  • Diarrhea
  • headache
  • indigestion
  • loss of appetite
  • nausea or vomiting
  • stomach pain
Less commonWith spinal injection
  • Back, leg, or neck pain
  • dizziness or lightheadedness
  • headache
  • nausea or vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of amphotericin B in the elderly with use in other age groups.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

  • Kidney disease—Amphotericin B may cause side effects affecting the kidneys

For Healthcare Professionals

Applies to amphotericin b: compounding powder, compounding powder for reconstitution, intravenous powder for injection, oral suspension

General

Oral amphotericin B is not appreciably absorbed, even at high dosage, and systemic adverse effects have not been noted.

Intravenous amphotericin B will lead to some intolerance in most patients, even at less than the full therapeutic dose. Tolerance can be improved by treatment with antipyretics, antihistamines, or antiemetics. Meperidine may decrease the duration of chills and fever that accompany infusion. Small doses of IV adrenal corticosteroids just prior to or during infusion may decrease febrile reactions. Heparin and use of a pediatric scalp-vein needle may lessen thrombophlebitis incidence.[Ref]

Renal

Very common (10% or more): Renal function test abnormalities (including azotemia, hyposthenuria, renal tubular acidosis, and nephrocalcinosis), blood creatinine increased
Common (1% to 10%): Renal failure acute
Uncommon (0.1% to 1%): Renal impairment
Rare (less than 0.1%): Nephrogenic diabetes insipidus[Ref]

Renal function test abnormalities usually improve upon interruption of therapy, however some permanent impairment often occurs, especially in patients receiving large cumulative doses (over 5 grams). Concomitant diuretic use may predispose patient for renal impairment, whereas sodium repletion/supplementation may reduce nephrotoxicity occurrence.[Ref]

Metabolic

Very common (10% or more): Hypokalemia
Common (1% to 10%): Hypomagnesemia, decreased appetite
Rare (less than 0.1%): Hyperkalemia
Frequency not reported: Hypocalcemia[Ref]

Gastrointestinal

Common (1% to 10%): Mild gastrointestinal distress, nausea, vomiting, diarrhea
Uncommon (0.1% to 1%): Abdominal pain upper
Rare (less than 0.1%): Dyspepsia, hemorrhagic gastroenteritis, melena
Frequency not reported: Transient yellowing of the teeth (oral route), cramping, epigastric pain[Ref]

Hematologic

Common (1% to 10%): Anemia
Uncommon (0.1% to 1%): Agranulocytosis, leukopenia, thrombocytopenia
Rare (less than 0.1%): Coagulopathy, eosinophilia, leukocytosis
Frequency not reported: Normochromic normocytic anemia[Ref]

Nervous system

Common (1% to 10%): Headache
Uncommon (0.1% to 1%): Neuropathy peripheral
Rare (less than 0.1%): Encephalopathy, convulsion, tinnitus, vertigo[Ref]

Hypersensitivity

Very rare (less than 0.01%): Anaphylactoid/anaphylactic reactions[Ref]

Cardiovascular

Cardiovascular side effects have been reported rarely. These have included hypotension, tachypnea, cardiac arrest, shock, cardiac failure, pulmonary edema, arrhythmia, including ventricular fibrillation, dyspnea, hypertension, and transient asystole. Thrombophlebitis has occurred in many patients because of the long duration of intravenous therapy usually required.[Ref]

Musculoskeletal

Chills usually occur within 15 to 20 minutes after initiation of infusion[Ref]

Very common (10% or more): Chills
Uncommon (0.1% to 1%): Myalgia
Rare (less than 0.1%): Arthralgia[Ref]

Respiratory

Very common (10% or more): Dyspnea
Uncommon (0.1% to 1%): Bronchospasm
Frequency not reported: Tachypnea, wheezing, pulmonary edema, hypersensitivity pneumonitis[Ref]

Hepatic

Common (1% to 10%): Liver function test abnormalities, hepatic function abnormal
Uncommon (0.1% to 1%): Jaundice
Rare (less than 0.1%): Acute hepatic failure[Ref]

Other

Very common (10% or more): Pyrexia
Rare (less than 0.1%): Deafness, pain and malaise, weight decreased
Frequency not reported: Hearing loss[Ref]

Dermatologic

Common (1% to 10%): Rash
Rare (less than 0.1%): Urticaria, angioedema, rash maculopapular, pruritus, skin exfoliation, Stevens-Johnson syndrome, toxic epidermal necrolysis[Ref]

Local

Common (1% to 10%): Injection site pain (with or without phlebitis or thrombophlebitis)[Ref]

Ocular

Rare (less than 0.1%): Vision blurred, diplopia
Frequency not reported: Visual impairment[Ref]

Genitourinary

Rare (less than 0.1%): Anuria, oliguria[Ref]

Some side effects of Amphocin may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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