Anakinra Subcutaneous

Name: Anakinra Subcutaneous

Commonly used brand name(s)

In the U.S.

  • Kineret

Available Dosage Forms:

  • Solution

Therapeutic Class: Immunological Agent

Pharmacologic Class: Interleukin-1 Inhibitor

Proper Use of anakinra

anakinra is given as a shot under your skin. Anakinra may sometimes be given at home to patients who do not need to be in the hospital or clinic. If you are using anakinra at home, your doctor or nurse will teach you how to prepare and inject the medicine. Be sure that you understand how to use the medicine.

anakinra comes with a Patient Information and Instructions for Use leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions.

If you use anakinra at home, you will be shown the body areas where this shot can be given. Use a different body area each time you give yourself or your child a shot. Keep track of where you give each shot to make sure you rotate body areas. This will help prevent skin problems.

Use a new needle, unopened prefilled syringe, or syringe each time you inject your medicine.

You might not use all of the medicine in each prefilled syringe. Use each syringe only one time. Do not save an open syringe. If the medicine in the syringe has changed color, or if you see particles in it, do not use it.

Use the medicine at the same time each day.

Throw the used needles away in a hard, closed container that the needles cannot poke through. Keep this container away from children and pets.

Dosing

The dose of anakinra will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of anakinra. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For injection dosage form (solution):
    • For rheumatoid arthritis:
      • Adults—100 milligrams (mg) per day injected under the skin.
      • Children—Use is not recommended.
    • For neonatal-onset multisystem inflammatory disease (NOMID):
      • Adults and children—Dose is based on body weight and must be determined by your doctor. The starting dose is usually 1 to 2 milligrams (mg) per kilogram (kg) of body weight injected under the skin per day. Your doctor may increase your dose as needed. However, the dose is usually not more than 8 mg per kg of body weight per day.

Missed Dose

If you miss a dose of anakinra, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store in the refrigerator. Do not freeze.

Do not shake the medicine. Protect it from light.

anakinra Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common
  • Diarrhea
  • fever or chills
  • headache
  • itching, pain, redness, swelling, tenderness or warmth on the skin
  • joint pain
  • muscle aches and pains
  • nausea or vomiting
  • runny nose or sneezing
  • sore throat
Less common or rare
  • Difficulty with swallowing
  • hives, itching, or rash
  • swelling of the face or lips
  • unusual bruising or bleeding
  • unusual tiredness or weakness
Incidence not known
  • Dizziness
  • fast heartbeat
  • hives or welts
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Abdominal or stomach pain
  • bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • difficulty with moving
  • headache
  • muscle aches or stiffness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Uses

This medication is used alone or with other medications to treat rheumatoid arthritis. It helps to slow joint damage and reduces the joint pain/swelling caused by rheumatoid arthritis so that you can move better. Anakinra is a man-made form of a natural protein (interleukin-1 receptor antagonist) made by the body. It helps to block the effects of another protein (interleukin-1) which can cause joint pain/swelling/stiffness.

Anakinra is also used to treat a certain condition called Neonatal-Onset Multisystem Inflammatory Disease (NOMID). It helps to improve symptoms of the disease such as fever, rash, joint pain, vomiting, and headache.

How to use Anakinra Syringe

Read the Patient Information Leaflet if available from your pharmacist before you start using anakinra and each time you get a refill. If you have any questions, consult your doctor or pharmacist.

If you are giving the shots yourself, you will be trained by a health care professional on how to properly prepare and inject this product. If any of the information is unclear, consult your health care professional.

This medication is injected under the skin (subcutaneously), usually once a day or as directed by your doctor.

Dosage is based on your medical condition and response to treatment.

Do not shake this medication. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Let the medication warm to room temperature for 30 minutes before injecting it.

Before injecting each dose, clean the injection site with rubbing alcohol. It is important to change the location of the injection site daily to avoid problem areas under the skin. Do not inject this medication in an area that is tender, red, bruised, or hard or which has scars or stretch marks.

Use this medication regularly to get the most benefit from it. To help you remember, use it at the same time each day.

Do not reuse the syringe. Learn how to store and discard needles and medical supplies safely. Consult your pharmacist for more details.

Tell your doctor if your condition does not improve or if it worsens.

Side Effects

Redness, bruising, swelling, and pain at the injection site may occur. These skin reactions are usually mild and may last 2 to 4 weeks. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Anakinra has caused very serious infections (such as skin/bone/joint infections, pneumonia). Tell your doctor right away if you develop signs of an infection, including: fever/chills, persistent sore throat, cough with mucus, spreading redness/swelling/tenderness of the skin, bone pain.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

List Anakinra Syringe side effects by likelihood and severity.
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