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Before taking hyoscyamine, tell your doctor about all of your medical conditions. Especially tell your doctor if you:
- are allergic to hyoscyamine or to any of its ingredients
- have or had glaucoma
- have or had heart, lung, liver, or kidney disease
- have congestive heart failure or cardiac arrhythmias
- have a urinary tract or intestinal obstruction
- have an enlarged prostate
- have ulcerative colitis (a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum)
- have myasthenia gravis.
- have hyperthyroidism
- have hypertension
- are having surgery, including dental surgery. Tell your doctor or dentist that you take hyoscyamine.
- are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking hyoscyamine, call your doctor.
Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.
What should I discuss with my healthcare provider before taking Anaspaz (hyoscyamine)?
Do not take hyoscyamine if you are allergic to it, or if you have:
an enlarged prostate or problems with urination;
severe ulcerative colitis, or toxic megacolon;
To make sure you can safely take hyoscyamine, tell your doctor if you have any of these other conditions:
heart disease, congestive heart failure;
a heart rhythm disorder;
high blood pressure;
overactive thyroid; or
hiatal hernia with GERD (gastroesophageal reflux disease).
FDA pregnancy category C. It is not known whether hyoscyamine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.
Hyoscyamine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Each Anaspaz orally disintegrating tablet contains 1-hyoscyamine sulfate 0.125 mg. Anaspaz may be taken orally (swallowed or chewed) or sublingually. Anaspaz tablets are compressed, light yellow and scored with the Ascher logo on one side and 225/295 on the other. Inactive ingredients: DC Yellow #10, FDC yellow #6, lactose NF, magnesium stearate NF, mannitol USP, sorbitol NF, pre-gelatinized starch NF, stearic acid NF.
Anaspaz is chemically pure 1-hyoscyamine sulfate, one of the principal anticholinergic/antispasmodic components of belladonna alkaloids. Chemically, it is benzeneacetic acid, α-(hydroxymethyl)-, 8-methyl-8-azabicyclo[3.2.1.]oct-3-yl ester, [3(S)-endo]-, sulfate (2:1), dihydrate with the chemical formula (C17H23NO3)2•H2SO4•2H2O
For the Consumer
Applies to hyoscyamine: oral conventional tablets and sublingual tablets, oral extended-release capsules and tablets, oral oral solution and elixir, oral orally disintegrating tablets, parenteral injection
Side effects include:
Most adverse effects are manifestations of pharmacologic effects at muscarinic-cholinergic receptors and usually are reversible when therapy is discontinued.
Severity and frequency of adverse effects are dose related and individual intolerance varies greatly; adverse effects occasionally may be obviated by a reduction in dosage but this also may eliminate potential therapeutic effects.
Adverse effects include dry mouth, urinary hesitancy and retention, blurred vision, tachycardia, palpitations, mydriasis, increased ocular tension, loss of taste, headache, nervousness, drowsiness, weakness, fatigue, dizziness, insomnia, nausea, vomiting, impotence, constipation, bloated feeling, abdominal pain, diarrhea, allergic reactions or drug idiosyncrasies, urticaria and other dermal manifestations, ataxia, speech disturbance, mental confusion and/or excitement (especially in geriatric patients), short-term memory loss, hallucinations, and decreased sweating.