Anesthetic, local Rectal

Name: Anesthetic, local Rectal

Commonly used brand name(s)

In the U.S.

  • AnaMantle HC
  • Colace
  • Fleet Babylax
  • Fleet Glycerin
  • Proctofoam-NS
  • Sani-Supp
  • Z-Pram
  • Zypram

In Canada

  • Tronothane

Available Dosage Forms:

  • Cream
  • Suppository
  • Foam

Uses For This Medicine

Rectal anesthetics are used to relieve the pain and itching of hemorrhoids (piles) and other problems in the rectal area. However, if you have hemorrhoids that bleed, especially after a bowel movement, check with your doctor before using this medicine. Bleeding may mean that you have a condition that needs other treatment.

These medicines are available without a prescription; however, your doctor may have special instructions on the proper use and dose for your medical problem.

Before Using This Medicine


Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Children may be especially sensitive to the effects of local anesthetics. This may increase the chance of side effects during treatment.


Elderly people are especially sensitive to the effects of local anesthetics. This may increase the chance of side effects during treatment.


Rectal anesthetics have not been reported to cause birth defects or other problems in humans.

Breast Feeding

Rectal anesthetics have not been reported to cause problems in nursing babies.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Acecainide
  • Amiodarone
  • Bretylium
  • Dofetilide
  • Ibutilide
  • Sotalol

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of medicines in this class. Make sure you tell your doctor if you have any other medical problems, especially:

  • Infection at or near place of treatment or
  • Large sores, broken skin, or severe injury at or near place of treatment—The chance of unwanted effects may be increased.

Precautions While Using This Medicine

Check with your doctor:

  • If your condition does not improve after you have been using this medicine regularly for 7 days, or if it becomes worse.
  • If any bleeding from the rectum occurs.
  • If you notice any rash, redness, or irritation that was not present before you started using this medicine.

False test results may occur if benzocaine or tetracaine is present in your body when a certain laboratory test is done. This test uses a medicine called bentiromide (e.g., Chymex) to show how well your pancreas is working. You should not use any products containing benzocaine or tetracaine for about 72 hours (3 days) before this test is done.

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Stop taking this medicine and get emergency help immediately if any of the following effects occur:

Signs and symptoms of too much medicine being absorbed by the body
  • Blurred or double vision
  • confusion
  • convulsions (seizures)
  • dizziness or lightheadedness
  • drowsiness
  • feeling hot, cold, or numb
  • increased sweating
  • ringing or buzzing in ears
  • shivering or trembling
  • slow or irregular heartbeat
  • unusual anxiety, excitement, nervousness, or restlessness
  • unusual paleness

Check with your doctor as soon as possible if any of the following side effects occur:

Less common
  • Burning, stinging, swelling, or tenderness not present before treatment
  • skin rash, redness, itching, or hives at or near place of application

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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