Anti-Diarrheal Tablet

Name: Anti-Diarrheal Tablet

Warnings

Allergy alert:

Do not use if you have ever had a rash or other allergic reaction to loperamide HCl

Do not use

if you have bloody or black stool

Ask a doctor before use if you have

  • a fever
  • mucus in the stool
  • a history of liver disease

Ask a doctor or pharmacist before use if you are

taking antibiotics

When using this product

  • tiredness, drowsiness, or dizziness may occur. Be careful when driving or operating machinery.

Stop use and ask a doctor if

  • symptoms get worse
  • diarrhea lasts for more then 2 days
  • you get abdominal swelling or bulging. These may be signs of a serious condition.

If pregnant or breast-feeding,

ask a health professional before use.

Keep out of reach of children.

In case of overdose, get medical help or contact a Poison Control Center right away.

Directions

  • drink plenty of clear fluids to help prevent dehydration caused by diarrhea
  • find right dose on chart. If possible, use weight to dose; otherwise, use age.
adults and
children
12 years and
over
2 caplets after the first loose
stool; 1 caplet after each
subsequent loose stool; but no
more than 4 caplets in 24 hours
children
9-11 years
(60-95 lbs)
1 caplet after the first loose stool;
1/2 caplet after each subsequent
loose stool; but no more than
3 caplets in 24 hours
children
6-8 years
(48-59 lbs)
1 caplet after the first loose stool;
1/2 caplet after each subsequent
loose stool; but no more than
2 caplets in 24 hours
children
under 6 years
(up to 47 lbs)
ask a doctor

Other Information

  • store between 20°-25°C (68°-77°F)
  • see end flap for expiration date and lot number

Questions or comments?

Call 1-800-426-9391 8:30 AM-4:00 PM ET, Monday-Friday

Usual Pediatric Dose for Diarrhea - Chronic

less than 2 years:
Therapeutic dose for the treatment of chronic diarrhea has not been established for this patient population.

Renal Dose Adjustments

Data not available

Precautions

Loperamide is considered contraindicated in patients with abdominal pain in the absence of diarrhea. Loperamide is not recommended as primary therapy in patients with acute dysentery characterized by blood in the stools and high fever, acute ulcerative colitis, bacterial enterocolitis caused by invasive organisms including Salmonella, Shigella, and Campylobacter, and in patients with pseudomembranous colitis associated with the use of broad-spectrum antibiotics. Loperamide is not recommended in infants less than 24 months of age.

Fluids and electrolytes should be replaced as necessary.

The use of loperamide is not recommended in patients in whom peristalsis is to be avoided due to the possible risk of significant sequelae (including ileus, megacolon, and toxic megacolon). Loperamide should be discontinued immediately in patients who develop constipation, abdominal distention, or ileus.

Whenever indicated and/or appropriate, the underlying etiology of the diarrhea should be determined and treated appropriately.

There are isolated reports of toxic megacolon in AIDS patients with infectious colitis (both viral and bacterial pathogens) treated with loperamide. Therefore, it is recommended to discontinue loperamide therapy in AIDS patients at the first sign of possible abdominal distention.

There are rare reports of allergic reactions including anaphylaxis and anaphylactic shock. Loperamide therapy should be stopped and a physician notified if symptoms get worse, diarrhea lasts for more than 48 hours, if blood is observed in the stools, or abdominal swelling or bulging occurs.

Caution is recommended in patients with hepatic dysfunction. In addition, these patients should be monitored closely for signs of central nervous system (CNS) toxicity.

Loperamide should be used with special caution in young children because of the greater variability of response in this age group. Dehydration, particularly in younger children, may further influence the variability of response to loperamide.

Loperamide may impair the mental abilities necessary for potentially hazardous tasks such as driving a car or operating machinery.

Other Comments

Maximum recommended dose for adults is 16 mg per day.

The duration of treatment for acute diarrhea generally does not exceed 48 hours.

Therapy should be accompanied by fluid and electrolyte replacement as needed.

Tolerance to the antidiarrheal effect of loperamide has not been reported.

Response and Effectiveness

Some effects may be seen within 20 minutes; however, takes about 2.5 hours (oral solution) or 5 hours (capsules) for loperamide to reach its peak effect.

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