Antihistamine / decongestant combination Oral

Name: Antihistamine / decongestant combination Oral

Side Effects of This Medicine

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Although serious side effects occur rarely when this medicine is taken as recommended, they may be more likely to occur if: too much medicine is taken, it is taken in large doses, or it is taken for a long period of time.

Get emergency help immediately if any of the following symptoms of overdose occur:

For promethazine only
  • Muscle spasms (especially of neck and back)
  • restlessness
  • shuffling walk
  • tic-like (jerky) movements of head and face
  • trembling and shaking of hands
  • Clumsiness or unsteadiness
  • convulsions (seizures)
  • drowsiness (severe)
  • dryness of mouth, nose, or throat (severe)
  • hallucinations (seeing, hearing, or feeling things that are not there
  • headache (continuing)
  • shortness of breath or troubled breathing
  • slow, fast, or irregular heartbeat
  • trouble in sleeping

Check with your doctor as soon as possible if any of the following side effects occur:

  • Back, leg or stomach pain
  • black, sticky stools
  • bleeding gums
  • blood, cloudy or dark urine, or sudden decrease in amount of urine
  • blood pressure increased
  • blurred vision
  • chest pain
  • confusion
  • diarrhea
  • dizziness
  • faintness, or lightheadedness when getting up from a lying or sitting position
  • fever or chills
  • light-colored stools
  • mood or mental changes
  • nosebleeds
  • sore throat and fever
  • skin rash or hives
  • stillbirth
  • swollen mouth, throat, face, fingers, feet, glands or lower legs
  • sweating suddenly
  • tightness in chest
  • troubled breathing
  • twitching, twisting, or uncontrolled repetitive movements of face
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting of blood
  • weight gain suddenly
  • yellow or pale eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common - rare with loratadine-containing combination
  • Drowsiness
  • thickening of the bronchial secretions
Less common - more common with high doses
  • Blurred vision
  • confusion
  • difficult or painful urination
  • dizziness
  • dryness of mouth, nose, or throat
  • headache
  • loss of appetite
  • nightmares
  • pounding heartbeat
  • ringing or buzzing in ears
  • skin rash
  • stomach upset or pain (more common with pyrilamine)
  • unusual excitement, nervousness, restlessness, or irritability
  • unusual sleepiness, weakness or drowsiness, extreme tiredness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

The information contained in the Thomson Healthcare (Micromedex) products as delivered by is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

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