Name: Arestin

Dosing & Uses

Dosage Forms & Strengths


  • 1mg


Varies depending on size, shape, & number of pockets

Up to 121 1-mg cartridges have been used in a single visit


Does not require local anesthesia

Insert unit-dose cartridge to the base of the periodontal pocket & press thumb ring in the handle mechanism to expel powder while gradually withdrawing the tip from pocket base

Handle mechanism should be sterilized between patients

Does not have to be removed (bioresorbable), nor is an adhesive or dressing required

Other Indications & Uses

Adjunct during dental scaling & root planing to reduce pocket depth in adults with periodontitis

Safety & efficacy not established



Hypersensitivity to minocycline or tetracyclines

Acutely abscessed periodontal pockets


May cause tooth discoloration in utero

Pregnancy & Lactation

Pregnancy Category: D

Lactation: tetracyclines excreted in milk, discontinue drug or do not nurse

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.


Mechanism of Action

Antibiotic of the tetracycline class


Distribution: saliva > serum

Patient Handout

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