Artane

Name: Artane

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to trihexyphenidyl.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Indications

ARTANE (trihexyphenidyl) is indicated as an adjunct in the treatment of all forms of parkinsonism (postencephalitic, arteriosclerotic, and idiopathic). It is often useful as adjuvant therapy when treating these forms of parkinsonism with levodopa. Additionally, it is indicated for the control of extrapyramidal disorders caused by central nervous system drugs such as the dibenzoxazepines, phenothiazines, thioxanthenes, and butyrophenones.

Warnings

Patients to be treated with ARTANE (trihexyphenidyl) should have a gonioscope evaluation prior to initiation of therapy and close monitoring of intraocular pressures. The use of anticholinergic drugs may precipitate angle closure with an increase in intraocular pressure. If blurring of vision occurs during therapy, the possibility of narrow angle glaucoma should be considered. Blindness has been reported due to aggravation of narrow angle glaucoma (see CONTRAINDICATIONS and ADVERSE REACTIONS)

ARTANE (trihexyphenidyl) should be administered with caution in hot weather, especially when given concomitantly with other atropine-like drugs to the chronically ill, alcoholics, those who have central nervous system disease, or those who do manual labor in a hot environment. Anhidrosis may occur more readily when some disturbance of sweating already exists. If there is evidence of anhidrosis, the possibility of hyperthermia should be considered. Dosage should be decreased so that the ability to maintain body heat equilibrium via perspiration is not impaired. Severe anhidrosis and fatal hyperthermia have occurred with the use of anticholinergics under the conditions described above.

Neuroleptic Malignant Syndrome

A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome (NMS) has been reported in association with dose reduction or discontinuation of trihexyphenidyl. Clinical manifestations of NMS are hyperpyrexia, muscle rigidity, altered mental status and evidence of autonomic instability (irregular pulse or blood pressure, tachycardia, diaphoresis and cardiac dysrhythmias).

The diagnostic evaluation of patients with this syndrome is complicated. In arriving at a diagnosis, it is important to identify cases where the clinical presentation includes both serious medical illness (eg, pneumonia, systemic infection, etc.) and untreated or inadequately treated extrapyramidal signs and symptoms (EPS). Other important considerations in the differential diagnosis include central anticholinergic toxicity, heat stroke, drug fever, and primary central nervous system (CNS) pathology.

What is Artane (trihexyphenidyl)?

Trihexyphenidyl alters unusual nerve impulses and relaxes stiff muscles.

Trihexyphenidyl is used to treat the stiffness, tremors, spasms, and poor muscle control of Parkinson's disease. It is also used to treat and prevent the same muscular conditions when they are caused by drugs such as chlorpromazine (Thorazine), fluphenazine (Prolixin), perphenazine (Trilafon), haloperidol (Haldol), thiothixene (Navane), and others.

Trihexyphenidyl may also be used for purposes other than those listed in this medication guide.

What happens if I miss a dose?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and only take the next regularly scheduled dose. Do not take a double dose of this medication.

Proper Use of trihexyphenidyl

This section provides information on the proper use of a number of products that contain trihexyphenidyl. It may not be specific to Artane. Please read with care.

Take this medicine every day exactly as ordered by your doctor in order to improve your condition as much as possible. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

You may take this medicine before or after food, although it is usually taken with meals.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (elixir or tablets):
    • For Parkinson's disease:
      • Adults—At first, 1 milligram (mg) once a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 15 mg per day, given in divided doses 3 or 4 times per day.
      • Children—Use and dose must be determined by your doctor.
    • For side effects caused by other medicines:
      • Adults—5 to 15 milligrams (mg) per day, given in divided doses 3 or 4 times per day.
      • Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

What is the most important information i should know about trihexyphenidyl (artane, trihexane)?

Use caution when driving, operating machinery, or performing other hazardous activities. Trihexyphenidyl may cause dizziness or blurred vision. If you experience dizziness or blurred vision, avoid these activities.

Use alcohol cautiously. Alcohol may increase drowsiness and dizziness while taking trihexyphenidyl.

Avoid becoming overheated. Trihexyphenidyl may cause decreased sweating. This could lead to heat stroke in hot weather or with vigorous exercise.

What happens if i miss a dose (artane, trihexane)?

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and only take the next regularly scheduled dose. Do not take a double dose of this medication.

Precautions

Trihexyphenidyl has cumulative effects. Therefore, continued supervision of the patient is recommended.

Trihexyphenidyl may impair mental and/or physical abilities. Patients should be cautioned about driving or operating dangerous machinery. The elderly may be particularly vulnerable to these effects.

Anticholinergic agents, including trihexyphenidyl, are not effective in controlling tardive dyskinesia (TD) and in some cases may aggravate it or induce previously suppressed symptoms. Trihexyphenidyl should be avoided in patients presenting with TD. If TD symptoms develop or worsen during treatment with trihexyphenidyl, prompt withdrawal of therapy will provide better chances of improving the condition.

Trihexyphenidyl occasionally intensifies mental symptoms in patients with preexisting psychiatric disorders.

Trihexyphenidyl should be used cautiously in patients with cardiac disorders, including a tachycardic tendency or hypertension, liver disorders, kidney disorders, prostatic hypertrophy, obstructive disease of the gastrointestinal or genitourinary tracts, or angle-closure glaucoma. Patients should have intraocular pressures checked at regular intervals.

Abrupt discontinuation of long-term trihexyphenidyl therapy may be associated with withdrawal and cholinergic rebound symptoms, including myalgias, diaphoresis, gastrointestinal distress, lethargy, depression, anxiety, tachycardia, orthostatic hypotension, hallucinations, and relapse or exacerbation of extrapyramidal effects. Withdrawal symptoms may be delayed by days to weeks after stopping medication.

Due to its hallucinogenic and euphorigenic effects, trihexyphenidyl is subject to potential misuse by drug abusers.

Since the use of trihexyphenidyl may, in some cases, continue indefinitely and since it has atropine-like properties, patients should be subjected to constant and careful long-term monitoring to avoid allergic and other untoward reactions.

Geriatric patients, particularly over the age of 60, commonly develop increased sensitivity to the actions of drugs of this type, and hence, require strict dosage regulation.

Dialysis

Data not available

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