Atropine Ophthalmic
Name: Atropine Ophthalmic
- Atropine Ophthalmic names
- Atropine Ophthalmic action
- Atropine Ophthalmic usual dose
- Atropine Ophthalmic dose range
- Atropine Ophthalmic dosage
- Atropine Ophthalmic tablet
- Atropine Ophthalmic drug
- Atropine Ophthalmic adverse effects
- Atropine Ophthalmic therapeutic effect
Brand names
- Atropine Care 1%
- Atropisol®
- Isopto® Atropine
- Ocu-Tropine®
What Is Atropine Ophthalmic?
Atropine causes the muscles in your eye to become relaxed. This widens (dilates) your pupil so that it will not respond to light.
Atropine ophthalmic (for the eye) is used to dilate your pupils when you have an inflammatory condition or in postsurgery situations in which this effect may be helpful.
Atropine ophthalmic is also used in people with a condition called amblyopia (sometimes called "lazy eye"). Atropine ophthalmic can be placed into the stronger eye to temporarily blur the vision in that eye. This helps strengthen the weaker eye because the brain will force that eye to work harder to focus.
Atropine ophthalmic may also be used for purposes other than those listed in this medication guide.
You should not use this medicine if you are allergic to atropine. You should not use the ointment form of this medicine if you have glaucoma.
You should not use this medicine if you are allergic to atropine. You should not use the ointment form of this medicine if you have glaucoma.
To make sure atropine ophthalmic is safe for you, tell your doctor if you have:
- high blood pressure;
- glaucoma.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant.
Atropine ophthalmic can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.
Do not give this medicine to a child younger than 3 months old.
Dosage Forms
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Ointment, Ophthalmic, as sulfate:
Generic: 1% (3.5 g)
Solution, Ophthalmic, as sulfate:
Atropine-Care: 1% (2 mL [DSC], 5 mL [DSC], 15 mL [DSC]) [contains benzalkonium chloride, edetate disodium]
Isopto Atropine: 1% (5 mL [DSC], 15 mL [DSC])
Generic: 1% (2 mL, 5 mL, 15 mL)
Onset of Action
Ophthalmic solution: Within minutes; maximum effect: within hours
Time to Peak
28 ± 27 minutes (range: 3 to 60 minutes)
Dosing Adult
Amblyopia, healthy eye penalization: Ophthalmic: Solution: Instill 1 drop in the conjunctiva 40 minutes prior to intended maximal dilation time; may repeat up to twice daily as needed.
Mydriasis/cycloplegia: Ophthalmic:
Solution: Instill 1 drop in the conjunctiva 40 minutes prior to intended maximal dilation time; may repeat up to twice daily as needed.
Ointment: Apply a small amount in the conjunctival sac 1 to 2 times daily.
Terminal respiratory secretions (off-label use): Sublingual (using 1% ophthalmic solution): Initial: 1 to 2 drops every 2 to 4 hours; usual dose range: 2 to 4 drops every 2 to 4 hours (Protus 2013)
Storage
Solution: Store at 2°C to 25°C (36°F to 77°F).
Ointment: Store at 15°C to 25°C (59°F to 77°F).
Drug Interactions
AbobotulinumtoxinA: Anticholinergic Agents may enhance the anticholinergic effect of AbobotulinumtoxinA. Monitor therapy
Acetylcholinesterase Inhibitors: Anticholinergic Agents may diminish the therapeutic effect of Acetylcholinesterase Inhibitors. Acetylcholinesterase Inhibitors may diminish the therapeutic effect of Anticholinergic Agents. Monitor therapy
Aclidinium: May enhance the anticholinergic effect of Anticholinergic Agents. Avoid combination
Amantadine: May enhance the anticholinergic effect of Anticholinergic Agents. Monitor therapy
Amifampridine: May diminish the anticholinergic effect of Anticholinergic Agents. Anticholinergic Agents may diminish the therapeutic effect of Amifampridine. Monitor therapy
Analgesics (Opioid): Anticholinergic Agents may enhance the adverse/toxic effect of Analgesics (Opioid). Specifically, the risk for constipation and urinary retention may be increased with this combination. Monitor therapy
Anticholinergic Agents: May enhance the adverse/toxic effect of other Anticholinergic Agents. Monitor therapy
Cannabinoid-Containing Products: Anticholinergic Agents may enhance the tachycardic effect of Cannabinoid-Containing Products. Exceptions: Cannabidiol. Monitor therapy
Chloral Betaine: May enhance the adverse/toxic effect of Anticholinergic Agents. Monitor therapy
Cimetropium: Anticholinergic Agents may enhance the anticholinergic effect of Cimetropium. Avoid combination
Eluxadoline: Anticholinergic Agents may enhance the constipating effect of Eluxadoline. Avoid combination
Gastrointestinal Agents (Prokinetic): Anticholinergic Agents may diminish the therapeutic effect of Gastrointestinal Agents (Prokinetic). Monitor therapy
Glucagon: Anticholinergic Agents may enhance the adverse/toxic effect of Glucagon. Specifically, the risk of gastrointestinal adverse effects may be increased. Avoid combination
Glycopyrrolate (Oral Inhalation): Anticholinergic Agents may enhance the anticholinergic effect of Glycopyrrolate (Oral Inhalation). Avoid combination
Ipratropium (Oral Inhalation): May enhance the anticholinergic effect of Anticholinergic Agents. Avoid combination
Itopride: Anticholinergic Agents may diminish the therapeutic effect of Itopride. Monitor therapy
Levosulpiride: Anticholinergic Agents may diminish the therapeutic effect of Levosulpiride. Avoid combination
MAO Inhibitors: May enhance the hypertensive effect of Atropine (Ophthalmic). Avoid combination
Mianserin: May enhance the anticholinergic effect of Anticholinergic Agents. Monitor therapy
Mirabegron: Anticholinergic Agents may enhance the adverse/toxic effect of Mirabegron. Monitor therapy
Nitroglycerin: Anticholinergic Agents may decrease the absorption of Nitroglycerin. Specifically, anticholinergic agents may decrease the dissolution of sublingual nitroglycerin tablets, possibly impairing or slowing nitroglycerin absorption. Monitor therapy
OnabotulinumtoxinA: Anticholinergic Agents may enhance the anticholinergic effect of OnabotulinumtoxinA. Monitor therapy
Oxatomide: May enhance the anticholinergic effect of Anticholinergic Agents. Avoid combination
Potassium Chloride: Anticholinergic Agents may enhance the ulcerogenic effect of Potassium Chloride. Management: Patients on drugs with substantial anticholinergic effects should avoid using any solid oral dosage form of potassium chloride. Avoid combination
Potassium Citrate: Anticholinergic Agents may enhance the ulcerogenic effect of Potassium Citrate. Avoid combination
Pramlintide: May enhance the anticholinergic effect of Anticholinergic Agents. These effects are specific to the GI tract. Consider therapy modification
Ramosetron: Anticholinergic Agents may enhance the constipating effect of Ramosetron. Monitor therapy
RimabotulinumtoxinB: Anticholinergic Agents may enhance the anticholinergic effect of RimabotulinumtoxinB. Monitor therapy
Secretin: Anticholinergic Agents may diminish the therapeutic effect of Secretin. Management: Avoid concomitant use of anticholinergic agents and secretin. Discontinue anticholinergic agents at least 5 half-lives prior to administration of secretin. Consider therapy modification
Thiazide and Thiazide-Like Diuretics: Anticholinergic Agents may increase the serum concentration of Thiazide and Thiazide-Like Diuretics. Monitor therapy
Tiotropium: Anticholinergic Agents may enhance the anticholinergic effect of Tiotropium. Avoid combination
Topiramate: Anticholinergic Agents may enhance the adverse/toxic effect of Topiramate. Monitor therapy
Umeclidinium: May enhance the anticholinergic effect of Anticholinergic Agents. Avoid combination
Pregnancy Considerations
Atropine crosses the placenta following systemic maternal use (Shutt 1979). Atropine is systemically available following ophthalmic administration. If ophthalmic agents are needed during pregnancy, the minimum effective dose should be used in combination with punctual occlusion to decrease potential exposure to the fetus (Samples 1988).
How should I use atropine ophthalmic?
Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Wash your hands before using eye medication.
To apply the eye drops:
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Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the dropper above the eye with the tip down. Look up and away from the dropper and squeeze out a drop.
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Close your eyes for 2 or 3 minutes with your head tipped down, without blinking or squinting. Gently press your finger to the inside corner of the eye for about 1 minute, to keep the liquid from draining into your tear duct.
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Use only the number of drops your doctor has prescribed. If you use more than one drop, wait about 5 minutes between drops.
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Wait at least 10 minutes before using any other eye drops your doctor has prescribed.
Do not use the eye drops if the liquid has changed colors or has particles in it. Call your pharmacist for new medicine.
To apply the ointment:
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Tilt your head back slightly and pull down your lower eyelid to create a small pocket. Hold the ointment tube with the tip pointing toward this pocket. Look up and away from the tip.
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Squeeze out a ribbon of ointment into the lower eyelid pocket without touching the tip of the tube to your eye. Blink your eye gently and then keep it closed for 1 or 2 minutes.
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Use a tissue to wipe excess ointment from your eyelashes.
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After opening your eyes, you may have blurred vision for a short time. Avoid driving or doing anything that requires you to be able to see clearly.
Do not touch the tip of the eye dropper or ointment tube or place it directly on your eye. A contaminated dropper or tube tip can infect your eye, which could lead to serious vision problems.
Store at room temperature away from moisture and heat. Do not freeze. Keep the bottle or tube tightly closed when not in use.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222 if you have used too much atropine ophthalmic, or if anyone has accidentally swallowed the medication.