Name: AVC

Dosing & Uses

Dosage Forms & Strengths

vaginal cream

  • 15%

Candida Vulvovaginitis

1 applicatorful (~6 g) intravaginally qDay or q12hr for 30 days

Safety & efficacy not established

Adverse Effects

Frequency Not Defined

Local sensitivity reactions (discomfort, burning)



Hypersensitivity to sulfonamides


Third trimester of pregnancy

Severe blook reactions including aplastic anemia, agranulocytosis, and other blood dyscrasias reported

Severe reactions including toxic epidermal necrolysis, and Stevens Johnson syndrome reported

Fulminant hepatic necrosis reported with sulfonamides regardless of route

Discontinue if skin rash reaction occurs

Pregnancy & Lactation

Pregnancy Category: C

Lactation: Not recommended

Pregnancy Categories

A: Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B: May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C: Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D: Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X: Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA: Information not available.

Patient Handout

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