Bacitracin

Name: Bacitracin

Overdose

No information provided.

Bacitracin Brand Names

Bacitracin may be found in some form under the following brand names:

  • AK-Tracin

  • Atopalm First Aid

  • Atopalm First Aid Moisturizing and Pain Relief

  • Baci-IM

  • Baciguent

  • Bacitraycin Plus

  • Betadine Antibiotic

  • Betadine Plus Antibiotic and Pain Reliever

  • Campho-Phenique Maximum Strength

  • Cortisporin Ointment

  • Cortomycin Ointment

  • Lanabiotic

  • Medi-Quik

  • Mycitracin Plus Pain Reliever

  • Mycitracin Triple Antibiotic

  • Neo-Polycin

  • Neo-Polycin HC

  • Neocidin Ointment

  • Neocin

  • Neosporin Ointment

  • Neosporin Plus Maximum Strength

  • Neosporin Plus Maximum Strength Ointment

  • Neotricin HC

  • Ocu-Cort

  • Ocu-Spore-B

  • Ocu-Tracin

  • Ocumycin

  • Ocutricin

  • Polycin-B

  • Polysporin

  • Polytracin

  • ProCoMycin

  • Rash Relief Antibacterial

  • Repara Triple Antibiotic

  • Septa

  • Spectrocin Plus

  • Tri Biozene

  • Tribiotic Plus

Bacitracin Drug Class

Bacitracin is part of the drug class:

  • OTHER ANTIBACTERIALS

Uses for Bacitracin

Staphylococcal Pneumonia and Empyema in Infants

Has been used IM in infants for treatment of pneumonia and empyema caused by susceptible staphylococci.100 104

Not considered a preferred or alternative agent for treatment of staphylococcal infections; other anti-infectives are used for treatment of staphylococcal respiratory tract infections.137 138 139

Manufacturers state use bacitracin only when adequate laboratory facilities are available and constant supervision of the patient is possible.100 104

Clostridium difficile-associated Diarrhea and Colitis (CDAD)

Has been used orally† for treatment of CDAD† (also known as antibiotic-associated diarrhea and colitis or pseudomembranous colitis).101 102 103 110 111 112 113 117 140 143 Designated an orphan drug by FDA for use in this condition.114

Oral bacitracin not recommended as a preferred or alternative agent for treatment of C. difficile infection (CDI) or CDAD.110 111 112 113 Bacitracin-resistant C. difficile reported,111 113 and the drug generally has been less effective that other anti-infectives used in management of CDAD.110 111 112 113 In addition, bacitracin oral preparations not commercially available in US.

Bacitracin Dosage and Administration

Administration

Administer IM.100 104

Has been administered orally†,101 102 103 112 113 117 140 143 but oral preparations not commercially available in US.

IM Injection

Inject into upper outer quadrant of the buttocks.100 104 Alternate injection sites between right and left side.100 104 Avoid making multiple injections in same region because of transient pain following injection.100 104

Reconstitution

Reconstitute lyophilized powder for injection by dissolving in 0.9% sodium chloride injection containing 2% procaine hydrochloride.100 104 If 9.8 mL of this diluent is used to reconstitute a vial containing 50,000 units of bacitracin, resultant solution contains 5000 units/mL.100 104

Do not use bacitracin solutions containing <5000 units/mL or >10,000 units/mL.100 104

Do not use diluents containing parabens;100 104 cloudy solutions and precipitate formation may occur.100 104

Dosage

Pediatric Patients

Staphylococcal Pneumonia and Empyema in Infants IM

Infants <2.5 kg: Manufacturers recommend 900 units/kg daily given in 2 or 3 divided doses.100 104

Infants >2.5 kg: Manufacturers recommend 1000 units/kg daily in 2 or 3 divided doses.100 104

Prescribing Limits

Pediatric Patients

Staphylococcal Pneumonia and Empyema in Infants

Do not exceed recommended dosage;100 104 duration >12 days not recommended.a

Special Populations

No special population dosage recommendations.100 104

Interactions for Bacitracin

Specific Drugs

Drug

Interaction

Comments

Aminoglycosides (kanamycin, neomycin, streptomycin)

Possible additive nephrotoxic effects14

Avoid concomitant use14 100 104

Colistimethate/colistin

Possible additive nephrotoxic effects14

Avoid concomitant use14 100 104

Polymyxin b sulfate

Possible additive nephrotoxic effects14 100 104

Avoid concomitant use14 100 104

Neuromuscular blocking agents and general anesthetics

Possible enhanced neuromuscular blockade if bacitracin used concomitantly during surgery or postoperatively14

Vancomycin

Possible additive nephrotoxic effects14

Avoid concomitant use14 100

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name

Bacitracin

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Parenteral

For injection, for IM use

50,000 units*

BACiiM

X-Gen

Bacitracin for Injection

PACKAGE/LABEL PRINCIPAL DISPLAY PANEL – 3.5 g Carton

Rx Only

NDC 0574-4022-35

Bacitracin Ophthalmic Ointment USP

NET WT 3.5 g (1/8 oz)

STERILE

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