Name: Bactocill

Oxacillin Dosage

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Take the medicine with a full glass of water.

Oxacillin should be taken on an empty stomach, at least 1 hour before or 2 hours after eating a meal.

To be sure this medication is helping your condition, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled visits to your doctor.

Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Oxacillin will not treat a viral infection such as the common cold or flu.

Do not share oxacillin with another person, even if they have the same symptoms you have.

This medication can cause you to have unusual results with certain medical tests. Tell any doctor who treats you that you are using oxacillin.

Store oxacillin at room temperature away from moisture, heat, and light.

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include confusion, behavior changes, a severe skin rash, urinating less than usual, or seizure (black-out or convulsions).

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. Do not take extra medicine to make up the missed dose.


IV Incompatibilities

Additive: amikacin(?), cytarabine

Syringe: caffeine

Y-site: Na bicarb, verapamil

Aminoglycosides & tetracyclines, but compatibility depends on several factors (eg, concentrations of the drugs, specific diluents used, resulting pH, temperature)

IV Compatibilities

Solution: compatible w/ most common solvents

Additive: Chloramphenicol Na succinate, dopamine, KCl, verapamil

Y-site (partial list): Acyclovir, diltiazem, fluconazole, heparin, hydromorphone, MgSO4, meperidine, morphine, KCl, vit B/C, zidovudine

IV/IM Preparation

IM Injection

  • For IM injection, reconstitute by adding 5.7 or 11.4 mL of SWI to a vial containing 1 or 2 g of oxacillin, respectively, to provide solutions containing 167 mg of oxacillin per mL (250 mg/1.5 mL)
  • Shake vials well

IV Injection

  • For direct injection, prepare a solution containing approximately 100 mg/mL by adding 10 or 20 mL SWI, ½NS or NS to vials containing 1 or 2 g of oxacillin, respectively

Intermittent or Continuous IV Infusion

  • For intermittent IV infusion, reconstitute vials containing 1 or 2 g as for direct IV injection & further dilute with a compatible IV solution to a concentration of 0.5-40 mg/mL
  • Alternatively, reconstitute ADD-Vantage vials containing 1 or 2 g according to the mfr's directions

IV/IM Administration

Administer by IM injection or slow IV injection or infusion

IM: deep into a large muscle (eg, gluteus maximus) & care should be taken to avoid sciatic nerve injury

IV Injection: slowly over about 10 min

Intermittent or Continuous IV Infusion: injections should not be used in series connections with other plastic containers: could result in air embolism from residual air being drawn from primary container before administration of fluid from secondary container is complete


Oxacillin powder: store at controlled room temp

Oxacillin in dextrose injection: store <-20°C


Antibacterial; β-lactam antibiotic; isoxazolyl penicillin classified as a penicillinase-resistant penicillin.1 4 5 9 46 70

Advice to Patients

  • Importance of discontinuing oxacillin and notifying clinician if evidence of hypersensitivity occurs.1

  • Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs.1

  • Importance of women informing clinician if they are or plan to become pregnant or plan to breast-feed.1

  • Importance of advising patients of other important precautionary information. (See Cautions.)

For the Consumer

Applies to oxacillin: parenteral injection, parenteral powder for injection

Side effects include:

Hypersensitivity reactions; local reactions (phlebitis, thrombophlebitis); renal, hepatic, or nervous system effects with high dosage.

Usual Adult Dose for Endocarditis

Manufacturer Recommendations: See Usual Adult Dose (Bacterial Infection)

American Heart Association (AHA) recommendations:
Native valve endocarditis due to staphylococci: 2 g IV every 4 hours or 3 g IV every 6 hours (total 12 g/day)

Duration of therapy:
Complicated right-sided infective endocarditis (IE), left-sided IE: 6 weeks
Uncomplicated right-sided IE: 2 weeks

-With optional addition of gentamicin 3 mg/kg/day IV or IM in 2 or 3 equally divided doses for 3 to 5 days.
-Refer to current published guidelines for detailed recommendations.

Prosthetic valve endocarditis due to staphylococci: 2 g IV every 4 hours (total 12 g/day)
Duration of therapy: 6 weeks or longer

-Plus rifampin 300 mg IV or orally every 8 hours for 6 weeks or longer.
-Plus gentamicin 3 mg/kg/day IV or IM in 2 or 3 equally divided doses for 2 weeks.
-Refer to current published guidelines for detailed recommendations.

Usual Adult Dose for Pneumonia

Manufacturer Recommendations: See Usual Adult Dose (Bacterial Infection)

Some experts recommend: 2 g IV or IM every 4 hours
Duration of therapy: Therapy should continue for 7 to 10 days if pneumococcus pneumonia is suspected and up to 21 days if other organisms are responsible.

Renal Dose Adjustments

Dose adjustment(s) may be required; however, no specific guidelines have been suggested. Caution recommended.

Some experts recommend:
Adults with CrCl less than 10 mL/min: The dose used should be the lower range of the usual dose.