Bee pollen

Name: Bee pollen

What is the most important information I should know about bee pollen?

Follow all directions on the product label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What happens if I miss a dose?

Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra bee pollen to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Bee Pollen Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives, itching; feeling light-headed; difficult breathing; swelling of your face, lips, tongue, or throat.

Although not all side effects are known, bee pollen is thought to be possibly safe when taken for up to 30 days.

Long-term use of bee pollen may cause serious side effects. Stop using bee pollen and call your healthcare provider at once if you have:

  • skin rash, bruising, severe tingling, numbness, pain, muscle weakness;
  • trouble breathing;
  • upper stomach pain, loss of appetite; or
  • swelling, rapid weight gain.

Common side effects may include:

  • numbness, tingling; or
  • upset stomach.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Clinical data regarding safety and efficacy in pregnancy and lactation are lacking. However, use in pregnant rats resulted in fetuses with higher birth weights and decreased death rates, suggesting that bee pollen may be an effective prenatal nutrient. 1


Research reveals little or no information regarding toxicity with the use of this product.

Bee pollen consists of plant pollens collected by worker bees combined with plant nectar and bee saliva, usually a mixture of pollen species from several different plants. The pollens are packed by the insects into small dust pellets that are then used as a food source for the male drones. Commercially, the pollen is gathered at the entrance of the hive by forcing the bees to enter through a portal partially obstructed with wire mesh that brushes the material off the hind legs into a collection vessel. Because of the increasing popularity of bee pollen as a health food, this means of pollen collection has been supplemented by collection directly from the hives.


The best recommended dose of bee pollen is unknown. Doses vary between products because tablets contain differing amounts of bee pollen. Manufacturers' recommendations may provide more guidance.


1. Xie Y, Wan B, Li W. Effect of bee pollen on maternal nutrition and fetal growth [in Chinese]. Hua Xi Yi Ke Da Xue Xue Bao . 1994;25(4):434-437.
2. Mirkin G. Can bee pollen benefit health? JAMA . 1989;262(13):1854.
3. Tyler VE. The Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies . 3rd ed. New York, NY: Pharmaceutical Products Press; 1992.
4. Steben RE, Boudreaux P. The effects of pollen and protein extracts on selected blood factors and performance of athletes. J Sports Med Phys Fitness . 1978;18(3):221-226.
5. Turner KK, Nielsen BD, O'Connor CI, Burton JL. Bee pollen product supplementation to horses in training seems to improve feed intake: A pilot study. J Anim Physiol Anim Nutr (Berl) . 2006;90(9-10):414-420.
6. Montgomery PL. Bee pollen: wonder drug or humbug? New York Times . February 6, 1977;5:1,7.
7. Blustein P. Pollinated presidents aside, experts doubt value of bee pick-me-up. Wall Street Journal . February 12, 1981.
8. Maughan RJ, Evans SP. Effects of pollen extract upon adolescent swimmers. Br J Sports Med . 1982;16(3):142-145.
9. Dhar NB, Shoskes DA. New therapies in chronic prostatitis. Curr Urol Rep . 2007;8(4):313-318.
10. MacDonald R, Ishani A, Rutks I, Wilt TJ. A systematic review of Cernilton for the treatment of benign prostatic hyperplasia. BJU Int . 2000;85(7):836-841.
11. Shoskes DA. Phytotherapy in chronic prostatitis. Urology . 2002;60 (suppl 6):35-37.
12. Shoskes DA, Manickam K. Herbal and complementary medicine in chronic prostatitis. World J Urol . 2003;21(2):109-113.
13. Wilt T, MacDonald R, Ishani A, Rutks I, Stark G. Cernilton for benign prostatic hyperplasia. Cochrane Database Syst Rev . 2000;(2):CD001042.
14. Elist J. Effects of pollen extract preparation Prostat / Poltit on lower urinary tract symptoms in patients with chronic nonbacterial prostatitis/chronic pelvic pain syndrome: a randomized, double-blind, placebo-controlled study. Urology . 2006;67(1):60-63.
15. Xu J, Qian WQ, Song JD. A comparative study on different doses of Cernilton for preventing the clinical progression of benign prostatic hyperplasia [in Chinese]. Zhonghua Nan Ke Xue . 2008;14(6):533-537.
16. Rugendorff EW, Weidner W, Ebeling L, Buck AC. Results of treatment with pollen extract ( Cernilton N ) in chronic prostatitis and prostatodynia. Br J Urol . 1993;71(4):433-438.
17. Wu YD, Lou YJ. A steroid fraction of chloroform extract from bee pollen of Brassica campestris induces apoptosis in human prostate cancer PC-3 cells. Phytother Res . 2007;21(11):1087-1091.
18. Einer-Jensen N, Zhao J, Andersen KP, Kristoffersen K. Cimicifuga and Melbrosia lack oestrogenic effects in mice and rats. Maturitas . 1996;25(2):149-153.
19. Winther K, Hedman C. Assessment of the effects of the herbal remedy Femal on the symptoms of premenstrual syndrome: a randomized, double-blind, placebo-controlled study. Curr Ther Res Clin Exp . 2002;63(5):344-353.
20. Georgiev DB, Metka M, Huber JC, Goudev AR, Manassiev N. Effects of an herbal medication containing bee products on menopausal symptoms and cardiovascular risk markers: results of a pilot open-uncontrolled trial. MedGenMed . 2004;6(4):46.
21. Kolarov G, Nalbanski B, Kamenov Z, et al. Possibilities for an individualized approach to the treatment of climacteric symptoms with phytoestrogens [in Bulgarian]. Akush Ginekol (Sofiia) . 2001;40(4):18-21.
22. Szanto E, Gruber D, Sator M, Knogler W, Huber JC. Placebo-controlled study of melbrosia in treatment of climacteric symptoms [in German]. Wien Med Wochenschr . 1994:144(7):130-133.
23. Liu X, Li L. Morphological observation of effect of bee pollen on intracellular lipofuscin in NIH mice [in Chinese]. Zhongguo Zhong Yao Za Zhi . 1990;15(9):561-563, 578.
24. Nakajima Y, Tsuruma K, Shimazawa M, Mishima S, Hara H. Comparison of bee products based on assays of antioxidant capacities. BMC Complement Altern Med . 2009;9:4.
25. Aliyazicioglu Y, Deger O, Ovali E, et al. Effects of Turkish pollen and propolis extracts on respiratory burst for K-562 cell lines. Int Immunopharmacol . 2005;5(11):1652-1657.
26. Saric A, Balog T, Sobocanec S, et al. Antioxidant effects of flavonoid from Croatian Cystus incanus L. rich bee pollen. Food Chem Toxicol . 2009;47(3):547-554.
27. Iarosh AA, Macheret EL, Iarosh AA, Zapadniuk BV. Changes in the immunological reactivity of patients with disseminated sclerosis treated by prednisolone and the preparation Proper-Myl [in Russian]. Vrach Delo . 1990;(2):83-86.
28. Cohen SH, Yunginger JW, Rosenberg N, Fink JN. Acute allergic reaction after composite pollen ingestion. J Allergy Clin Immunol . 1979;64(4):270-274.
29. Lin FL, Vaughan TR, Vandewalker ML, Weber RW. Hypereosinophilia, neurologic, and gastrointestinal symptoms after bee-pollen ingestion. J Allergy Clin Immunol . 1989;83(4):793-796.
30. Geyman JP. Anaphylactic reaction after ingestion of bee pollen. J Am Board Fam Pract . 1994;7(3):250-252.
31. Greenberger PA, Flais MJ. Bee pollen-induced anaphylactic reaction in an unknowingly sensitized subject. Ann Allergy Asthma Immunol . 2001;86(2):239-242.
32. Pitsios C, Chliva C, Mikos N, Kompoti E, Nowak-Wegryzn A, Kontou-Fili K. Bee pollen sensitivity in airborne pollen allergic individuals. Ann Allergy Asthma Immunol . 2006;97(5):703-706.
33. Palanisamy A, Haller C, Olson KR. Photosensitivity reaction in a woman using an herbal supplement containing ginseng, goldenseal, and bee pollen. J Toxicol Clin Toxicol . 2003;41(6):865-867.
34. Shad JA, Chinn CG, Brann OS. Acute hepatitis after ingestion of herbs. South Med J .1999;92(11):1095-1097.

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