Benemid

Name: Benemid

Probenecid Side Effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • worsening gout symptoms;
  • severe pain in your side or lower back;
  • blood in your urine;
  • swelling, especially in your face, stomach, ankles, or feet; or
  • pale or yellowed skin, dark colored urine, fever, confusion or weakness.

Less serious side effects may include:

  • urinating more than usual;
  • mild nausea, vomiting, loss of appetite;
  • headache, dizziness;
  • sore gums;
  • mild itching or skin rash;
  • hair loss; or
  • warmth, redness, or tingly feeling under your skin.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Probenecid Dosage

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Drink plenty of water to prevent kidney stones while you are taking probenecid.

Probenecid may be only part of a complete program of treatment that also includes diet, other medications, and mineral supplements. Follow your doctor's instructions.

To be sure this medication is not causing harmful effects, your blood or urine may need to be tested on a regular basis. Do not miss any scheduled appointments.

If you are taking probenecid together with an antibiotic, be sure to read the medication guide or patient instructions provided with each of your medications. Do not change your doses or medication schedule without advice from your doctor.

If you need to have any type of surgery, tell the surgeon ahead of time that you are taking probenecid. This medication may affect your body's response to anesthesia.

Store probenecid at room temperature away from moisture and heat.

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include nausea, vomiting, or stomach upset.

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What is Benemid (probenecid)?

Probenecid helps your body pass uric acid out through the urine, which lowers the levels of uric acid in the body.

Probenecid is used to treat gout and gouty arthritis. Probenecid is also sometimes given together with penicillin antibiotics to make them more effective.

Probenecid may also be used for other purposes not listed in this medication guide.

How should I take Benemid (probenecid)?

Take this medication exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

Drink plenty of water to prevent kidney stones while you are taking probenecid.

Probenecid may be only part of a complete program of treatment that also includes diet, other medications, and mineral supplements. Follow your doctor's instructions.

To be sure this medication is not causing harmful effects, your blood or urine may need to be tested on a regular basis. Do not miss any scheduled appointments.

If you are taking probenecid together with an antibiotic, be sure to read the medication guide or patient instructions provided with each of your medications. Do not change your doses or medication schedule without advice from your doctor.

If you need to have any type of surgery, tell the surgeon ahead of time that you are taking probenecid. This medication may affect your body's response to anesthesia.

Store probenecid at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

Usual Adult Dose for Gouty Arthritis

Therapy should not be started until an acute gout attack has subsided:

Initial: 250 mg orally twice a day for 1 week
Maintenance: 500 mg orally twice a day
-If symptoms of gouty arthritis are not controlled or 24-hour uric acid excretion is not above 700 mg, may increase dose in 500 mg increments every 4 weeks as tolerated; continue at dose that maintains normal serum urate levels
Maximum dose: 2 g per day

Comments:
-If an acute attack is precipitated during therapy, this drug should be continued at same dose while appropriate therapy is given to control acute attack.
-To prevent crystallization of uric acid in urine, a liberal fluid intake (2 L/day) and alkalization of the urine should be encouraged; alkalization of urine may be relaxed when serum urate levels return to normal limits and tophaceous deposits disappear.
-Maintenance dose may be decreased in increments of 500 mg every 6 months when acute attacks have been absent for 6 months or more and serum urate levels remain within normal limits; maintenance dosage should not be reduced to the point serum urate levels start to rise.

Use: For the treatment of hyperuricemia associated with gout and gouty arthritis.

Usual Adult Dose for Adjunct to Antibiotic Therapy

500 mg orally 4 times a day

Comment: The Centers for Disease Control and Prevention (CDC) no longer recommend this drug with oral cephalosporins or ampicillin as a treatment for gonococcal infections.

Use: As an adjuvant to therapy with penicillin or with ampicillin, methicillin, oxacillin, cloxacillin, or nafcillin, for elevation and prolongation of plasma levels by whatever route the antibiotic is given.

Precautions

Contraindicated in children less than 2 years of age

Consult WARNINGS section for additional precautions.

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