Benzoyl peroxide and clindamycin Topical application

Name: Benzoyl peroxide and clindamycin Topical application

Uses For benzoyl peroxide and clindamycin

Benzoyl peroxide and clindamycin combination is used to treat acne. It works by killing the bacteria that cause acne and by keeping the skin pores clean (tiny openings on the skin).

benzoyl peroxide and clindamycin is available only with your doctor's prescription.

Proper Use of benzoyl peroxide and clindamycin

It is very important that you use benzoyl peroxide and clindamycin only as directed. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause your skin to become irritated. You may need to use benzoyl peroxide and clindamycin for several weeks or months before your skin starts to look better. Applying extra medicine will not make it work faster.

benzoyl peroxide and clindamycin is for use on the skin only. Do not get it in your eyes, nose, mouth, or vagina. Do not use it on skin areas that have cuts or scrapes. If it does get on these areas, rinse it off right away.

benzoyl peroxide and clindamycin should come with a patient information insert. Read and follow these instructions carefully. Ask your doctor if you have any questions.

To use:

  • Wash your hands with soap and water before and after using benzoyl peroxide and clindamycin.
  • Before applying benzoyl peroxide and clindamycin, wash the affected area of your skin with warm water and a mild soap. Rinse well and pat dry.
  • Apply a small amount of the medicine to each affected area of the skin (eg, forehead, chin, cheeks, chest, shoulders), and gently rub it in.


The dose of benzoyl peroxide and clindamycin will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of benzoyl peroxide and clindamycin. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For topical dosage form (gel):
    • For acne:
      • Adults and children 12 years of age and older—
        • Benzaclin®: Apply a thin layer to the affected area(s) of the skin two times a day (morning and evening).
        • Duac®: Apply a thin layer to the affected area(s) of the face once a day, in the evening, or as directed by your doctor.
      • Children younger than 12 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of benzoyl peroxide and clindamycin, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Throw away any unused Duac® gel after 60 days or Benzaclin® gel after 3 months.

benzoyl peroxide and clindamycin Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common
  • Dry skin
Less common
  • Burning, itching, redness, skin rash, swelling, or soreness at the application site
  • flushing or redness of the skin
  • peeling
  • sunburn
  • unusually warm skin
Incidence not known
  • Cough
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • hives or skin rash
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • tightness in the chest
  • unusual tiredness or weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

For the Consumer

Applies to benzoyl peroxide / clindamycin topical: external gel, external kit

Liver Dose Adjustments

Data not available

Other Comments

Benzoyl peroxide-clindamycin gel may be stored at room temperature (up to 77 degrees Fahrenheit) and should be discarded after 3 months (BenzaClin) or 2 months (Acanya and Duac). It should not be allowed to freeze.

Benzoyl peroxide-clindamycin may bleach hair and colored fabrics.