Chloramphenicol Ophthalmic Ointment

Name: Chloramphenicol Ophthalmic Ointment

Description

Each gram of Chloromycetin Ophthalmic Ointment, 1% contains 10 mg of chloramphenicol in a special base of liquid petrolatum and polyethylene. It contains no preservatives. Sterile ointment.

The chemical names for chloramphenicol are:

  1. Acetamide, 2,2-dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl) ethyl]-, and
  2. D-threo-(—)-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-p-nitrophenethyl] acetamide.

Chloramphenicol has the following empirical and structural formulas:

Indications

Chloramphenicol should be used only in those serious infections for which less potentially dangerous drugs are ineffective or contraindicated. Bacteriological studies should be performed to determine the causative organisms and their sensitivity to chloramphenicol (see BOX WARNING).

Chloromycetin Ophthalmic Ointment, 1% (Chloramphenicol Ophthalmic Ointment, USP) is indicated for the treatment of surface ocular infections involving the conjunctiva and/or cornea caused by chloramphenicol-susceptible organisms.

The particular antiinfective drug in this product is active against the following common bacterial eye pathogens:

Staphylococcus aureus
Streptococcus,
including Streptococcus pneumoniae
Escherichia coli

Haemophilus influenzae

Klebsiella/Enterobacter
species
Moraxella lucunata
  (Morax-Axenfeld bacillus)
Neisseria
species

This product does not provide adequate coverage against:

Pseudomonas aeruginosa
Serratia marcescens

Side effects

Blood dyscrasias have been reported in association with the use of chloramphenicol (see WARNINGS).

Allergic or inflammatory reactions due to individual hypersensitivity and occasional burning or stinging may occur with the use of Chloromycetin Ophthalmic Ointment.

Overdose

No Information Provided

Patient information

No information provided. Please refer to the WARNINGS and PRECAUTIONS sections.

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