Donepezil-memantine Oral Capsule

Name: Donepezil-memantine Oral Capsule

Highlights for donepezil-memantine

Memantine/donepezil is an oral drug that’s used to treat moderate to severe dementia. It’s used in people with Alzheimer’s disease who are already stabilized on 10 mg of donepezil once daily.

This drug contains two medications in a single form, and they work in different ways to treat dementia.

Memantine/donepezil comes as an extended-release capsule. It’s available as a generic drug and as a brand-name drug called Namzaric.

Common side effects include diarrhea, nausea, vomiting, headache, loss of appetite, dizziness, and bruising. In most cases, these side effects are mild and temporary, lasting up to three weeks.

Call your doctor right away if you have a slow heart rate, fainting, or symptoms of a stomach ulcer or bleeding.

IMPORTANT INFORMATION
  • Slow heart rate/fainting See Details

  • Stomach bleeding/ulcers See Details

What is memantine/donepezil?

Memantine/donepezil is a prescription drug. It’s available as an extended-release oral capsule that combines the two drugs memantine and donepezil in a single form.

Memantine/donepezil is a generic drug that is also available as the brand-name drug Namzaric. Generic drugs usually cost less. In some cases, they may not be available in every strength or form as the brand-name version.

Why it's used

This drug is used to treat moderate to severe dementia in people with Alzheimer’s disease. This medication is for people who are stable on certain doses of donepezil.

More Details

How it works

A class of drugs refers to medications that work similarly. They have a similar chemical structure and are often used to treat similar conditions.

More Details

Donepezil-memantine Side Effects

Most Common Side Effects

The most common side effects that occur with memantine/donepezil include:

  • nausea

  • vomiting

  • diarrhea

  • headache

  • dizziness

  • not wanting to eat (anorexia)

  • bruising

  • trouble sleeping

  • muscle cramps

  • tiredness

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening or if you think you’re experiencing a medical emergency, call 9-1-1.

  • slow heart rate and fainting. Your risk may be higher if you have heart problems.

  • stomach ulcers and bleeding. Your risk may be higher if you have a history of ulcers or take drugs like aspirin or other nonsteroidal anti-inflammatory drugs (NSAIDs). Symptoms include:

    • heartburn
    • stomach pain that won’t go away
    • nausea or vomiting
    • blood in your vomit, or dark vomit that looks like coffee grounds
    • bowel movements or stools that look like black tar
  • trouble passing urine

  • seizures

  • worsening of lung problems in people with asthma or other lung diseases

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Donepezil-memantine May Interact with Other Medications

Memantine/donepezil can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Medications that might interact with this drug

Alzheimer’s disease medications

These drugs work similarly to donepezil. Taking them together may increase your risk for side effects.

These drugs include:

  • galantamine
  • rivastigmine
Anesthesia medications

These medications work similarly to memantine/donepezil. This may increase your risk for side effects.

These drugs include:

  • ketamine
  • succinylcholine
Antacids

Some drugs can lower the acidity of your urine. This can reduce the amount of memantine that’s removed from your body by your kidneys. This can increase your risk for side effects.

These drugs include:

  • sodium bicarbonate
Antifungal medications

These drugs can increase the levels of donepezil in your body. This can increase your risk for side effects.

These drugs include:

  • ketoconazole
Antihistamines

Donepezil can interfere with how these medications work.

These drugs include:

  • dimenhydrinate
  • diphenhydramine
  • hydroxyzine
Cough medications

These medications work similarly to memantine/donepezil. This may increase your risk for side effects.

These drugs include:

  • dextromethorphan
Depression medications

Donepezil can interfere with how these medications work.

These drugs include:

  • amitriptyline
  • desipramine
  • doxepin
  • nortriptyline
Glaucoma medications

Some drugs can lower the acidity of your urine. This can reduce the amount of memantine that’s removed from your body by your kidneys. This can increase your risk for side effects.

These drugs include:

  • acetazolamide
  • methazolamide
Heart medications

These drugs can increase the levels of donepezil in your body. This can increase your risk for side effects.

These drugs include:

  • quinidine
Overactive bladder (OAB) medications

Donepezil can interfere with how these medications work.

These drugs include:

  • darifenacin
  • oxybutynin
  • tolterodine
  • trospium
Parkinson's disease medications

These medications work similarly to memantine/donepezil. This may increase your risk for side effects.

These drugs include:

  • amantadine
Seizure medications

These drugs can decrease the levels of donepezil in your body. This can affect how well donepezil works to treat your Alzheimer’s disease.

These drugs include:

  • phenytoin
  • carbamazepine
  • phenobarbital
Steroids

These drugs can decrease the levels of donepezil in your body. This can affect how well donepezil works to treat your Alzheimer’s disease.

These drugs include:

  • dexamethasone
Stomach medications

Donepezil can interfere with how these medications work.

These drugs include:

  • dicyclomine
  • hyoscyamine
  • loperamide
Tuberculosis medications

These drugs can decrease the levels of donepezil in your body. This can affect how well donepezil works to treat your Alzheimer’s disease.

These drugs include:

  • rifampin
Urinary retention medications

These drugs work similarly to donepezil. Taking them together may increase your risk for side effects.

These drugs include:

  • bethanechol
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking. Drug warnings

People with heart problems

Let your doctor know if you have heart problems, especially issues with irregular, slow, or fast heart rate. You have a higher risk of having a slow heart rate and fainting while taking this drug.

People with stomach ulcers or bleeding

Talk to your doctor if you have a history of stomach problems, ulcers, or bleeding. This drug may increase the amount of acid in your stomach. This may put you at risk of having another stomach ulcer or bleed.

People with breathing or lung problems

Talk to your doctor if you have asthma or other lung diseases, such as chronic obstructive pulmonary disease (COPD). Taking this drug may make your condition worse.

People with seizures or epilepsy

This drug may cause seizures. Tell your doctor if you have a history of seizures or epilepsy. Alzheimer’s disease may also cause seizures.

People with bladder problems

This drug may block your bladder, making it harder to pass urine. Talk to your doctor if you’ve had any bladder problems in the past.

People with severe kidney problems

Your doctor may give you a lower dose of this drug if you have severe kidney problems. This may help reduce your chance of side effects.

People with severe liver problems

If your liver isn’t working well, more of this drug may stay in your body longer. This puts you at greater risk for side effects. If you have severe liver disease, your doctor will decide if this medication is safe for you to take.

Pregnant women

There is not enough information available to determine the risk to the fetus if a pregnant woman takes this drug. It isn’t known if it can harm an unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant. Memantine/donepezil should be used during pregnancy only if the potential benefit justifies the potential risk.

Women who are breast-feeding

It isn’t known if this medication passes into breast milk. If it does, it may cause side effects in a child who is breastfed. Talk to your doctor if you breastfeed your baby. You may need to decide whether to stop breastfeeding or stop taking this medication.

For seniors

As you age, your organs (such as your liver and kidneys) may not work as well as they did compared to when you were younger. More of the drug may stay in your body longer, putting you at risk for side effects.

For children

The safety and effectiveness of this drug in children under 18 years of age haven’t been established.

When to call the doctor

Call your doctor if you plan to have surgery or other medical procedures. When this drug is taken with certain anesthesia medicines, it may cause muscle problems. Tell your doctor if you have surgeries or dental or medical procedures planned.

Allergies

This drug can cause a severe allergic reaction. Symptoms include:

  • trouble breathing or swallowing
  • swelling of your face, lips, throat, or tongue
  • hives

Don’t take this drug again if you’ve ever had an allergic reaction to it, its individual components (memantine or donepezil), or piperidines. Taking it again could be fatal (cause death).

How to Take donepezil-memantine (Dosage)

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Dementia caused by Alzheimer’s disease

Brand: Namzaric

Form: extended release oral capsule Strengths:
  • 7 mg memantine hydrochloride extended-release/10 mg donepezil hydrochloride
  • 14 mg memantine hydrochloride extended-release/10 mg donepezil hydrochloride
  • 21 mg memantine hydrochloride extended-release/10 mg donepezil hydrochloride
  • 28 mg memantine hydrochloride extended-release/10 mg donepezil hydrochloride

Generic: Memantine/donepezil

Form: extended release oral capsule Strengths:
  • 14 mg memantine hydrochloride extended-release/10 mg donepezil hydrochloride
  • o28 mg memantine hydrochloride extended-release/10 mg donepezil hydrochloride
Adult dosage (ages 18–64 years)

For people who are stable on 10 mg donepezil daily:

  • Typical starting dosage: 7 mg memantine/10 mg donepezil once per day in the evening.
  • Dosage increases: Your dosage should be increased in 7-mg increments of memantine until it reaches a maintenance dosage of 28 mg memantine/10 mg donepezil per day. Your doctor should wait at least 7 days between dosage increases.
  • Maximum dosage: 28 mg memantine/10 mg donepezil once daily.

For people who are stable on 10 mg memantine twice daily, or 28 mg of extended-release memantine and 10 mg donepezil once daily, you can be switched to 28 mg memantine/10 mg donepezil once per day in the evening.

Child dosage (ages 0–17 years)

Namzaric hasn’t been studied in children and shouldn’t be used in children under the age of 18 years.

Special considerations

People with severe kidney problems:

For people who are stable on donepezil 10 mg daily:

  • Typical starting dosage: 7 mg memantine/10 mg donepezil once per day in the evening.
  • Dosage increases: Your dosage should be increased in 7-mg increments of memantine to a maintenance dosage of 14 mg memantine/10 mg donepezil once per day in the evening. Your doctor should wait at least 7 days between dosage increases.

For people who are stable on memantine (5 mg taken twice daily or 14 mg extended-release taken once daily) and donepezil 10 mg taken once daily, you can be switched to 14 mg memantine/10 mg donepezil once per day in the evening.

People with severe liver problems: If your liver isn’t working well, more Namzaric may stay in your body longer. This puts you at greater risk of side effects. Your doctor will decide if this medication is safe for you.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you. Important considerations for taking this drug

You can take this drug with or without food

Take this drug once per day in the evening

Don’t divide, chew, or crush the capsule

See Details

Store this medication at room temperature of 77°F (25°C)

See Details

A prescription for this medication is refillable

See Details

Travel

See Details

Clinical monitoring

See Details

Insurance

See Details

Are there any alternatives?

(web3)